H2S mitigates severe acute pancreatitis through the PI3K/AKT-NF-κB pathway in vivo

Figure 2 Levels of amylase, interleukin-6, and myeloperoxidase in pancreatic tissue. A: Plasma amylase level; B: Pancretic histology (HE × 200) [1: Control (saline-injected) pancreas; 2: L-Arg-induced severe acute pancreatitis (the arrow indicates edema, destruction, histoarchitecture bleeding of the acini and the inflammatory cell infiltration); 3: Rats pre-administered PAG 50 mg/kg show more severe destruction and histoarchitecture bleeding of the acini and inflammatory cell infiltration; 4: Pretreatment with NaHS at 5 mg/kg; 5: Pretreatment with NaHS at 10 mg/kg; 6: Pretreatment with NaHS at 15 mg/kg; 7: Pretreatment with NaHS at 100 mg/kg]; C: Plasma IL-6 level; D: MPO activity in the pancreatic tissue. ^aP < 0.05 vs the control; ^cP < 0.05 vs the SAP group. PAG: Propargylglycine; MPO: Myeloperoxidase; SAP: Severe acute pancreatitis.