Direct-acting antiviral-based triple therapy on alpha-fetoprotein level in chronic hepatitis C patients

Table 4 Alanine aminotransferase level change at each testing point

Group	Triple therapyALT level (U/L)					Dual therapyALT level (U/L)
	n	At baseline	At end of treatment	At 24 wk after the end of treatment	P value1	n	At baseline	At end of treatment	At 24 wk after the end of treatment	P value1
All patients	88	56.6 ± 4.1	25.9 ± 2.4	22.7 ± 1.8	< 0.001	122	64.1 ± 4.7	29.4 ± 4.0	35.3 ± 3.0	< 0.001
Treatment outcome
SVR	75	54.3 ± 4.3	25.4 ± 2.7	17.8 ± 1.1	< 0.001	52	74.0 ± 7.3	18.8 ± 1.6	14.9 ± 0.8	< 0.001
Non-SVR	13	69.8 ± 12.2	28.8 ± 3.8	50.6 ± 6.0	0.147	70	56.8 ± 4.9	37.4 ± 6.7	50.4 ± 4.3	0.169
Baseline ALT level
≥ 40 U/L	49	81.4 ± 5.1	32.9 ± 3.5	28.5 ± 2.8	< 0.001	78	84.3 ± 5.4	36.6 ± 5.9	40.0 ± 4.2	< 0.001
< 40 U/L	39	25.4 ± 1.2	17.1 ± 2.6	15.4 ± 1.3	< 0.001	44	28.3 ± 1.1	16.0 ± 1.7	26.8 ± 3.0	0.637
Previous treatment response
Naïve/Prior relapse	59	56.5 ± 5.2	25.5 ± 2.7	19.4 ± 1.5	< 0.001
Prior NVR	27	56.7 ± 7.5	21.0 ± 2.5	28.6 ± 4.5	< 0.001
IL28B SNP (rs8099917)
TT	49	56.9 ± 5.4	26.6 ± 3.8	17.4 ± 1.3	< 0.001	73	63.6 ± 5.4	18.9 ± 1.4	25.9 ± 2.4	< 0.001
TG/GG	39	56.2 ± 6.5	24.9 ± 2.6	29.2 ± 3.5	< 0.001	31	65.9 ± 9.4	38.8 ± 6.2	50.9 ± 5.2	0.073
Stage of fibrosis
F0-2	52	51.6 ± 5.2	23.1 ± 3.2	17.6 ± 1.5	< 0.001	76	63.4 ± 5.4	21.1 ± 1.7	25.4 ± 2.4	< 0.001
F3-4	12	68.8 ± 11.6	32.3 ± 5.6	27.5 ± 5.4	0.008	8	93.0 ± 25.8	34.8 ± 7.6	46.5 ± 11.8	0.172

¹Between baseline and 24 wk after the end of treatment. Treatment response was analyzed by per-protocol analysis. Data are expressed as mean ± SE. Dual therapy: Pegylated-interferon-α and ribavirin; IL28B: Interleukin 28B; NVR: Non-virological response; SNP: Single-nucleotide polymorphism; SVR: Sustained virological response; Triple therapy: Telaprevir-based therapy combined with pegylated-interferon-α and ribavirin; ALT: Alanine aminotransferase.