Direct-acting antiviral-based triple therapy on alpha-fetoprotein level in chronic hepatitis C patients

Table 3 Serum alpha-fetoprotein level change at each testing point

Group	Triple therapySerum AFP level (ng/mL)					Dual therapySerum AFP level (ng/mL)
	n	At baseline	At end of treatment	At 24 wk after the end of treatment	P value1	n	At baseline	At end of treatment	At 24 wk after the end of treatment	P value1
All patients	88	8.8 ± 1.4	5.1 ± 0.4	4.4 ± 0.4	< 0.001	122	7.8 ± 0.9	6.2 ± 1.3	7.0 ± 1.5	0.316
Treatment outcome
SVR	75	7.8 ± 1.5	4.5 ± 0.4	3.5 ± 0.2	0.004	52	4.7 ± 0.6	3.1 ± 0.2	2.8 ± 0.2	< 0.001
Non-SVR	13	14.3 ± 2.3	8.3 ± 1.1	9.5 ± 1.2	0.007	70	10.2 ± 1.5	8.7 ± 2.2	10.1 ± 2.5	0.953
Baseline AFP level
≥ 10 ng/mL	20	24.8 ± 4.4	10.5 ± 1.0	8.9 ± 0.8	0.003	26	21.8 ± 3.0	17.1 ± 5.3	20.2 ± 6.4	0.701
< 10 ng/mL	68	4.1 ± 0.2	3.4 ± 0.2	3.1 ± 0.2	< 0.001	96	4.1 ± 0.2	3.2 ± 0.2	3.4 ± 0.2	< 0.001
Previous treatment response
Naïve/prior relapse	59	8.8 ± 1.9	4.8 ± 0.5	3.8 ± 0.3	0.007
Prior NVR	27	9.1 ± 1.5	5.5 ± 0.8	5.8 ± 0.9	< 0.001
IL28B SNP (rs8099917)
TT	49	6.2 ± 1.0	3.9 ± 0.4	3.6 ± 0.3	< 0.001	73	6.0 ± 0.7	3.7 ± 0.3	3.9 ± 0.3	< 0.001
TG/GG	39	12.0 ± 2.8	6.5 ± 0.8	5.5 ± 0.6	< 0.001	31	10.2 ± 1.6	8.8 ± 2.9	9.3 ± 2.2	0.520
Stage of fibrosis
F0-2	52	6.5 ± 1.4	4.2 ± 0.5	3.3 ± 0.3	0.014	76	6.0 ± 0.7	3.7 ± 0.3	4.3 ± 0.5	< 0.001
F3-4	12	12.2 ± 3.0	6.5 ± 0.8	6.8 ± 1.1	0.023	8	13.6 ± 3.2	9.2 ± 3.2	9.9 ± 3.8	0.284

¹Between baseline and 24 wk after the end of treatment. Treatment response was analyzed by per-protocol analysis. Data are expressed as mean ± SE. Dual therapy: Pegylated-interferon-α and ribavirin; IL28B: Interleukin 28B; NVR: Non-virological response; SNP: Single-nucleotide polymorphism; SVR: Sustained virological response; Triple therapy: Telaprevir-based therapy combined with pegylated-interferon-α and ribavirin; AFP: Alpha-fetoprotein.