Pancreatic fat and β-cell function in overweight/obese children with nonalcoholic fatty liver disease

Table 2 Metabolic variables of overweight/obese children with and without nonalcoholic fatty liver disease

	NAFLD	No NAFLD	P value
	(n = 80)	(n = 78)
Triglycerides, mg/dL	101 (60)	84 (43)	0.045
Total cholesterol, mg/dL	152 (32)	158 (32)	0.220
HDL-C, mg/dL	46 (14)	48 (13)	0.430
Aspartate aminotransferase, U/L	24 (21-30)	22 (19-25)	0.007
Alanine aminotransferase, U/L	30 (20-44)	17 (14-23)	< 0.0001
γ-glutamyl transferase, U/L	17 (13-22)	13 (10-16)	< 0.0001
Fasting glucose, mg/dL	84 (8)	82 (5)	0.090
2-h glucose, mg/dL	94 (24)	90 (15)	0.310
Fasting insulin, mU/mL	19 (13)	13 (8)	0.001
2-h insulin, mU/mL	71 (67)	39 (30)	< 0.0001
Fasting C peptide, pmol/L	1009 (358)	769 (244)	< 0.0001
HOMA-IR values	3.8 (2.7)	2.7 (1.7)	0.003
WBISI	4.45 (2.95)	6.45 (3.69)	< 0.0001
HbA1c, %	5.2 (0.3)	5.1 (0.4)	0.750
HSCRP, μg/L	2200 (900-3950)	1300 (600-3150)	0.002

HDL-C: High-density lipoprotein cholesterol; HOMA-IR: Homeostasis model assessment of insulin resistance; HbA1c: Hemoglobin A1c; HSCRP: High-sensitivity C-reactive protein; NAFLD: Nonalcoholic fatty liver disease; WBISI: Whole-body insulin sensitivity index.