Preparation of magnetic resonance probes using one-pot method for detection of hepatocellular carcinoma

Figure 6 Transmission electron microscopy demonstrates the structure of the HepG2 cells under a magnification of × 10000. A: HepG2 cell with expression of GPC3 receptors incubated with anti-GPC3-USPIONs probes, and the probes were seen on the surface of the cell and in the cell (black aggregation); B: HepG2 cell with expression of AFP receptors incubated with anti-AFP-USPIONs probes, and the probes were seen in the cell (black aggregation); C: HepG2 cell with expression of GPC3 receptors incubated with USPIONs probes, and no USPION was seen. USPION: Ultrasmall superparamagnetic iron oxide nanoparticle; AFP: α-fetoprotein; GPC3: Glypican 3.