Th22 cell accumulation is associated with colorectal cancer development

Figure 2 Expression of Th22 cells and related cytokines in colorectal cancer. A: Gated on FSC/SSC and CD4⁺ subset, the proportion of Th22 cells in the CD4⁺ subset is presented in quadrant Q1; B: Average proportion of Th22 cells in tumor and paratumor tissues; C: Expression levels of interleukin-22, AHR, CCL20, CCL22 and CCL27 in tumor and paratumor tissues were measured by RT-qPCR. The relative expression levels were normalized to the level of β-actin mRNA for each sample. Each bar represents the mean ± SE (n = 50), ^aP < 0.05, tumor vs paratumor. NS: Not significant.