Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure

Figure 3 Thalidomide reduction of splenic pulp pressure and systolic blood pressure is endothelial and inducible nitric oxide synthase independent. 7 d portal vein ligation wild type, endothelial nitric oxide synthase (eNOS)^-/- and inducible nitric oxide synthase (iNOS)^-/- mice were treated with 50 mg/kg thalidomide or dimethyl sulfoxide vehicle control ip. Splenic pulp pressure (A) and systolic blood pressure (B) were measure 60 min after administration. Thalidomide reduced splenic pulp pressure and systolic pulp pressure in wild type, eNOS^-/- and iNOS^-/- mice (n = 4 mice per group, ^aP < 0.05 vs control group).