Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure

Figure 2 Thalidomide temporarily ameliorates splenic pulp pressure and mean systolic blood pressure in 7 d portal vein ligation mice. A: 7 d wild type sham and portal vein ligation (PVL) mice were treated with 50 mg/kg thalidomide ip and splenic pulp pressure was measured 0-150 min following administration. Splenic pulp pressure was rapidly and temporarily decreased by thalidomide; after 2 h pressure returned back to pre-thalidomide levels; B: Systolic blood pressure was also measured in 7 d PVL wild type mice following the administration of 50 mg/kg thalidomide or vehicle control. In a similar manner to splenic pulp pressure the systolic blood pressure was temporarily decreased by thalidomide. ^aP < 0.05 vs control group.