Meta-Analysis
Copyright ©The Author(s) 2015.
World J Gastroenterol. Apr 14, 2015; 21(14): 4345-4357
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4345
Table 1 Baseline characteristic of studies included in the systematic review and meta-analysis
StudyPatients (n)Age (yr)Methods of diagnosisMethods of assessmentProbiotic regimensEradication therapy regimens and dosage (mg/d)1
Navarro-Rodriguez et al[39], 2013107AdultsUBT + HA + Giemsa + RUTUBT + HA + Giemsa + RUTLacto + Bifido + Strep400F + 60La/60M + 1000Te
Ahmad et al[40], 201366ChildrenRUT/HAHpSALacto + Bifido + Strep3000A + 360F + 60M
Shavakhi et al[41],2013180AdultsRUT/HAUBTLacto + Bifido + Strep2000A + 480B + 1000C + 40M
Kyriakos et al[42], 201370AdultsRUT + HAUBTSaccha2000A + 1000C + 40M
Jiang et al[43], 2013280AdultsRUT + GiemsaUBTBacillus2000A + 60La + 3000Le
Dajani et al[44], 20132301BothUBT/RUT/HA/HpSAUBTBifido2000A + 1000C/800Me + PPI
Deguchi et al[45], 2012229AdultsCulture/(HA + RUT)(UBT + HpSA) + CultureLacto1500A + 400C + 20R
Tolone et al[46], 201268ChildrenUBT + HAUBTLacto + Bifido + Strep6000A + 1800C + 60M
Mirzaee et al[47], 20122102AdultsUBTUBTNM2000A + 1000C + 40P
Manfredi et al[48], 20122227AdultsRUT/HpSAHpSALacto + Bifido + Strep2000A + 1000C + 40E + 1000Ti
Du et al[49], 20122234AdultsUBT/RUT/GiemsaUBTLacto + Bacillus + Strep2000A + 1000C + 40M
Bekar et al[50], 201182AdultsUBTUBTLacto + Bifido2000A + 1000C + 60La
Yoon et al[51], 2011337NMUBT/RUT/HAUBTLacto + Bifido + Strep2000A + 1000C + 80E
He et al[52], 201184AdultsUBT + RUTUBT + RUTLacto + Bifido + Entero2000A + 1000C + (40-60)R + 1000Ti
Xu et al[53], 2010120NM(UBT/RUT) + HAUBTLacto + Bifido + Entero2000A + (20-40)E + 200F
Yaşar et al[54], 201076AdultsHAUBTBifido2000A + 1000C + 80P
Wen et al[55], 2010200NMUBT + RUTUBTLacto + Bifido + Entero2000A + 40P + 800Ti
Song et al[56], 20102991AdultsRUT/HAUBTSaccha2000A + 1000C + 40M
Szajewska et al[57], 200983Children2 of (UBT, RUT, HA)UBTLacto3000A + 1200C + 60M
Hurduc et al[58], 200990ChildrenRUT + HARUT + HASaccha3000A + 1800C + 60E/60M
Francavilla et al[59], 200840NM3 of (UBT, RUT, HA, HpSA)UBT + HpSALacto2000A + 1000C + 40R + 1000Ti (sequential)
Kim et al[60], 2008347AdultsUBT/RUT/HAUBTLacto + Bifido + Strep2000A + 1000C + PPI
Huang et al[61], 2008120NMUBT + RUTUBTLacto + Bifido + Entero1000C + (20-40)E/(20-40)R + 1000Rn
Imase et al[62], 2008219NMNMNMClost1500A + 800C + 60La
Cindoruk et al[63], 2007124AdultsHA + GiemsaUBTSaccha2000A + 1000C + 60La
Park et al[64], 2007352AdultsHAUBTBacillus + Strep2000A + 1000C + 40M
de Bortoli et al[65], 2007206NMHA/(UBT + HpSA)UBTLacto + Bifido + Strep2000A + 1000C + 40E
Sahagún-Flores et al[66], 200771AdultsHAUBTLacto2000A + 1000C + 40M
Lionetti et al[67], 200640Children2 of (UBT, RUT, HA)UBTLacto3000A + 900C + 60M + 1200Ti (sequential)
Goldman et al[68], 200665ChildrenUBTUBTLacto + Bifido3000A + 900C + 60M
Sheu et al[69], 2006138NMUBT + HAUBTLacto + Bifido + Strep2000A + 360B + 40M + 1000Me
Ziemniak et al[70], 20062245AdultsUBTUBTLacto2000A + 1000C + 80P
Sýkora et al[71], 200586Children2 of (RUT, HA, culture) + HpSAUBT + HpSALacto3000A + 900C + (1200-2400)M
Myllyluoma et al[72], 200547AdultsUBT + EIAUBTLacto + Bifido + Propionibacterium2000A + 1000C + 60La
Duman et al[73], 2005389NMUBT + HANMSaccha2000A + 1000C + 40M
Shimbo et al[74], 200535NMRUT + CultureUBTClost3000A + 800C + 120La
Cao et al[75], 2005128NMUBT + RUTUBT + RUTLacto + Bifido + Entero2000A + 300B + 40M + 800Me
Nista et al[76], 2004106AdultsUBTUBTBacillus2000A + 1000C + 40R
Tursi et al[77], 200470NMRUT + HAUBTLacto3000A + 800B + 40E/40P + 1000Ti
Guo et al[78], 200497AdultsRUT + HAUBTClost1000A + 200F + 40M
Sheu et al[79], 2002160NM(RUT/HA) + UBTUBT/RUT/HALacto + Bifido2000A + 1000C + 60La
Cremonini et al[80], 2002285AdultsUBTUBTLacto1000C + 40R + 1000Ti
Armuzzi et al[81], 2001a60AdultsUBT + EIAUBTLacto1000C + 40R + 1000Ti
Armuzzi et al[82], 2001b120AdultsUBT + EIAUBTLacto1000C + 80P + 1000Ti
Canducci et al[83], 2000120NMUBT + HAUBT + HALacto1500A + 750C + 40R
1“400F + 60L + 1000Te” means “Furazolidon 400 mg/d, lansoprazole 60 mg/d, and tetracycline 1000 mg/d”. Patient’s weight were assumed as 60 kg to calculate the exact dosage if only the dosage per kg were available in the article;
2These articles were designed with multiple arms, but only relevant groups were combined and included in this meta-analysis. UBT: Urea breath test; RUT: Rapid urease test; HA: Histological assessment; Giemsa: Giemsa staining; HpSA: H. pylori stool antigen test; EIA: Enzyme-linked immunosorbent Assay; Culture: Culture test; Lacto: Lactobacillus; Bifido: Bifidobacterium; Strep: Streptococcus; Saccha: Saccharomyces; Entero: Enterococcus; Clost: Clostridium; A: Amoxicillin; B: Bismuth subcitrate; C: Clarithromycin; E: Esomeprazole; F: Furazolidon; La: Lansoprazole; Le: Levofloxacin; M: omeprazole; Me: Metronidazole; P: Pantoprazole; PPI: Proton pump inhibitor; R: Rabeprazole; Rn: Ornidazole; Ti: Tinidazole; Te: Tetracyline; NM: Not mentioned.