Carbohydrate antigen 19-9 for differential diagnosis of pancreatic carcinoma and chronic pancreatitis

Table 3 Bivariate estimates of diagnostic precision based on different carbohydrate antigen 19-9 assay methods and cut-off values

Assay method or cut-off value	Number of studies	Number of participants	Sensitivity (95%CI)	Specificity (95%CI)	PLR (95%CI)	NLR (95%CI)	DOR (95%CI)
ELISA	11	1396	0.83 (0.80-0.86)	0.79 (0.75-0.82)	3.97 (2.96-5.33)	0.20 (0.15-0.28)	22.64 (12.44-41.22)
RIA	17	3074	0.82 (0.80-0.84)	0.81 (0.79-0.83)	4.16 (3.09-5.60)	0.23 (0.19-0.27)	20.14 (13.27-30.55)
EIA	3	427	0.75 (0.70-0.80)	0.79 (0.70-0.86)	3.84 (1.82-8.10)	0.34 (0.27-0.43)	10.29 (4.96-21.34)
LIA	2	224	ND	ND	ND	ND	ND
Cut-off of 37 U/mL	30	4879	0.82 (0.80-0.83)	0.80 (0.78-0.82)	3.94 (3.24-4.78)	0.24 (0.21-0.28)	18.79 (13.67-25.82)
Cut-off of 100 U/mL	3	297	0.69 (0.61-0.76)	0.85 (0.79-0.91)	4.35 (2.86-6.61)	0.38 (0.18-0.77)	11.53 (4.47-29.77)
All studies	34	5115	0.81 (0.80-0.83)	0.81 (0.79-0.82)	4.08 (3.39-4.91)	0.24 (0.21-0.28)	19.31 (14.40-25.90)

DOR: Diagnostic odds ratio; EIA: Enzyme immunoassay; ELISA: Enzyme-linked immunosorbent assay; LIA: Luminescent immunoassay; ND: Not done; NLR: Negative likelihood ratio; PLR: Positive likelihood ratio; RIA: Radioimmunoassay.