Carbohydrate antigen 19-9 for differential diagnosis of pancreatic carcinoma and chronic pancreatitis

Table 2 Additional characteristics of patients and methodology in the included studies

Ref.	Country/area	PC/CP, n	PC reference	Cross-sectional design	Consecutive or Random sampling	Blinded design	Prospective design
Wang et al[21], 1986	Taiwan	24/34	His or Cyt	No	Yes	No	Yes
Safi et al[22], 1987	Germany	87/104	His	Yes	Yes	No	Yes
Sakamoto et al[23], 1987	Japan	30/27	His	No	Yes	No	Yes
Friess et al[24], 1993	Germany	59/95	His	Yes	Yes	No	Yes
Röthlin et al[25], 1993	Switzerland	68/29	His	No	Yes	No	Yes
Haglund et al[26], 1994	Finland	179/20	His	No	Yes	No	Yes
Kuno et al[27], 1994	Japan	47/70	His	Yes	Yes	No	Yes
Pasquali et al[28], 1994	Italy	58/45	His	No	No	NR	Yes
Satake et al[29], 1994	Japan	641/300	His	Yes	Yes	No	Yes
Hámori et al[30], 1997	Hungary	62/32	His	No	Yes	No	Yes
Safi et al[31], 1997	Germany	347/300	His or Bio	Yes	Yes	No	Yes
Hayakawa et al[32], 1999	Japan	27/49	His (Bio, Aut)	No	Yes	No	Yes
Kim et al[33], 1999	Korea	90/70	His	Yes	Yes	No	Yes
Manes et al[34], 1999	Italy	34/24	His or Cyt	Yes	Yes	No	Yes
Slesak et al[35], 2000	Poland	48/74	His	No	Yes	No	Yes
Maire et al[36], 2002	France	47/31	His or Cyt	No	Yes	No	Yes
Akashi et al[37], 2003	Japan	20/26	His or Aut	No	Yes	No	Yes
Mu et al[38], 2003	China	9/15	His or Cyt	No	Yes	No	Yes
Cwik et al[39], 2004	Lublin	98/52	His	NR	Yes	NR	Yes
Jiang et al[40], 2004	China	96/52	His	Yes	Yes	No	Yes
Ventrucci et al[41], 2004	Italy	60/21	His	Yes	Yes	No	Yes
Teich et al[42], 2005	Germany	30/16	His	No	No	No	Yes
Chang et al[43], 2007	Taiwan	72/39	His	Yes	Yes	No	Yes
	New York, United States	28/34	His	No	Yes	NR	Yes
Kuhlmann et al[44], 2007	China	112/38	His	No	Yes	No	Yes
Liao et al[45], 2007	India	34/50	His or Bio	Yes	Yes	No	Yes
Bedi et al[46], 2009	United States	75/32	His or Cyt	Yes	Yes	No	Yes
	Taiwan	58/44	His	Yes	Yes	No	Yes
Firpo et al[47], 2009	United Kingdom	73/115	His	Yes	Yes	No	Yes
Liao et al[48], 2009	Poland	85/72	His	Yes	Yes	No	Yes
Morris-Stiff et al[49], 2009	Spain	47/55	His	Yes	Yes	No	Yes
Talar-Wojnarowska et al[50], 2010	Korea	55/23	His	Yes	Yes	No	Yes
Zapico-Muñiz et al[51], 2010	New York, United States	234/50	His or Cyt	Yes	Yes	No	Yes
Chung et al[52], 2011	Germany	91/23	His	No	Yes	No	Yes

Aut: Autopsy; Bio: Biopsy; CP: Chronic pancreatitis; Cyt: Cytology; PC: Pancreatic carcinoma; His: Histology; NR: Not reported.