Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients

doi:10.3748/wjg.v21.i14.4310

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2015; 21(14): 4310-4322
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4310

Table 3 Associations between polymorphisms of tagging SNPs in GST genes and overall survival in hepatocellular carcinoma patients

Gene	Tagging SNP	Genotype	Outcome, n (%)		HR (95%CI)	P value
Gene	Tagging SNP	Genotype	Dead	Alive	HR (95%CI)	P value
GSTA1	rs6917150	WW	48 (51.6)	45 (48.4)	1 (ref)
		WV + VV	63 (52.1)	58 (47.9)	1.01 (0.69-1.48)	0.961
GSTA4	rs385636	WW	82 (55.4)	66 (44.6)	1 (ref)
		WV + VV	29 (43.9)	37 (56.1)	0.71 (0.46-1.09)	0.117
GSTM2	rs638820	WW	42 (51.9)	39 (48.1)	1 (ref)
		WV + VV	69 (51.9)	64 (48.1)	1.13 (0.77-1.67)	0.526
GSTM3	rs1109138	WW	85 (54.1)	72 (45.9)	1 (ref)
		WV + VV	26 (45.6)	31 (54.4)	0.81 (0.52-1.26)	0.353
	rs7483	WW	63 (56.2)	49 (43.8)	1 (ref)
		WV + VV	48 (47.1)	54 (52.9)	0.94 (0.64-1.38)	0.760
GSTO1	rs2282326	WW	60 (56.1)	47 (43.9)	1 (ref)
		WV + VV	51 (47.7)	56 (52.3)	0.92 (0.63-1.35)	0.675
	rs17116779	WW	99 (51.0)	95 (49.0)	1 (ref)
		WV + VV	12 (60.0)	8 (40.0)	0.95 (0.52-1.75)	0.869
GSTO2	rs156699	WW	64 (50.0)	64 (50.0)	1 (ref)
		WV + VV	47 (54.7)	39 (45.3)	1.10 (0.75-1.62)	0.612
	rs7085725	WW	81 (46.0)	95 (54.0)	1 (ref)
		WV + VV	30 (78.9)	8 (21.1)	1.60 (1.03-2.47)^a	0.035^a
	rs157077	WW	50 (58.1)	36 (41.9)	1 (ref)
		WV + VV	61 (47.7)	67 (52.3)	0.78 (0.54-1.14)	0.198
GSTP1	rs4147581	WW	57 (55.3)	46 (44.7)	1 (ref)
		WV + VV	54 (48.6)	57 (51.4)	0.68 (0.46-0.99)^a	0.042^a
	rs2370141	WW	74 (52.1)	68 (47.9)	1 (ref)
		WV + VV	37 (51.4)	35 (48.6)	0.90 (0.61-1.34)	0.597

^aP < 0.05 was considered statistically significant. WW: Homozygous wild-type genotype; WV: Heterozygous genotype; VV: Homozygous variant genotype; SNP: Single nucleotide polymorphisms.

Citation: Qu K, Liu SS, Wang ZX, Huang ZC, Liu SN, Chang HL, Xu XS, Lin T, Dong YF, Liu C. Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients. World J Gastroenterol 2015; 21(14): 4310-4322
URL: https://www.wjgnet.com/1007-9327/full/v21/i14/4310.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i14.4310