Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients

doi:10.3748/wjg.v21.i14.4310

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 21, Issue 14

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7630)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-6) series, Tables (1-6) series.

Item

Count

PDF

420

WORD

199

HTML

3869

Figures (1-6)

183

Tables (1-6)

174

Sum=4845

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1254

Download

1531

Sum=2785

Apr 14, 2015 (publication date) through Nov 7, 2024

Times Cited of This Article

Times Cited (18)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Prospective Study

World J Gastroenterol. Apr 14, 2015; 21(14): 4310-4322
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4310

Table 3 Associations between polymorphisms of tagging SNPs in GST genes and overall survival in hepatocellular carcinoma patients

Gene	Tagging SNP	Genotype	Outcome, n (%)		HR (95%CI)	P value
Gene	Tagging SNP	Genotype	Dead	Alive	HR (95%CI)	P value
GSTA1	rs6917150	WW	48 (51.6)	45 (48.4)	1 (ref)
		WV + VV	63 (52.1)	58 (47.9)	1.01 (0.69-1.48)	0.961
GSTA4	rs385636	WW	82 (55.4)	66 (44.6)	1 (ref)
		WV + VV	29 (43.9)	37 (56.1)	0.71 (0.46-1.09)	0.117
GSTM2	rs638820	WW	42 (51.9)	39 (48.1)	1 (ref)
		WV + VV	69 (51.9)	64 (48.1)	1.13 (0.77-1.67)	0.526
GSTM3	rs1109138	WW	85 (54.1)	72 (45.9)	1 (ref)
		WV + VV	26 (45.6)	31 (54.4)	0.81 (0.52-1.26)	0.353
	rs7483	WW	63 (56.2)	49 (43.8)	1 (ref)
		WV + VV	48 (47.1)	54 (52.9)	0.94 (0.64-1.38)	0.760
GSTO1	rs2282326	WW	60 (56.1)	47 (43.9)	1 (ref)
		WV + VV	51 (47.7)	56 (52.3)	0.92 (0.63-1.35)	0.675
	rs17116779	WW	99 (51.0)	95 (49.0)	1 (ref)
		WV + VV	12 (60.0)	8 (40.0)	0.95 (0.52-1.75)	0.869
GSTO2	rs156699	WW	64 (50.0)	64 (50.0)	1 (ref)
		WV + VV	47 (54.7)	39 (45.3)	1.10 (0.75-1.62)	0.612
	rs7085725	WW	81 (46.0)	95 (54.0)	1 (ref)
		WV + VV	30 (78.9)	8 (21.1)	1.60 (1.03-2.47)^a	0.035^a
	rs157077	WW	50 (58.1)	36 (41.9)	1 (ref)
		WV + VV	61 (47.7)	67 (52.3)	0.78 (0.54-1.14)	0.198
GSTP1	rs4147581	WW	57 (55.3)	46 (44.7)	1 (ref)
		WV + VV	54 (48.6)	57 (51.4)	0.68 (0.46-0.99)^a	0.042^a
	rs2370141	WW	74 (52.1)	68 (47.9)	1 (ref)
		WV + VV	37 (51.4)	35 (48.6)	0.90 (0.61-1.34)	0.597

^aP < 0.05 was considered statistically significant. WW: Homozygous wild-type genotype; WV: Heterozygous genotype; VV: Homozygous variant genotype; SNP: Single nucleotide polymorphisms.

Citation: Qu K, Liu SS, Wang ZX, Huang ZC, Liu SN, Chang HL, Xu XS, Lin T, Dong YF, Liu C. Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients. World J Gastroenterol 2015; 21(14): 4310-4322
URL: https://www.wjgnet.com/1007-9327/full/v21/i14/4310.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i14.4310