Interleukin-21 gene polymorphisms and chronic hepatitis B infection in a Chinese population

Table 4 Interleukin-21 polymorphisms among non-hepatocellular carcinoma subgroups and controls n (%)

Polymorphism		Carrier	CHB	Cirrhosis	Control	Carrier vs control		CHB vs control		Cirrhosis vs control
		(n = 101)	(n = 76)	(n = 95)	(n = 208)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)
rs13143866
Allele frequency	Allele G	170 (84.2)	128 (84.2)	156 (82.1)	363 (87.3)		Reference		Reference		Reference
	Allele A	32 (15.8)	24 (15.8)	34 (17.9)	53 (12.7)	0.294	1.289 (0.802-2.073)	0.348	1.284 (0.761-2.166)	0.095	1.493 (0.933-2.388)
Genotype frequency	GG	75 (74.3)	53 (69.7)	64 (67.4)	157 (75.5)		Reference		Reference		Reference
	GA	20 (19.8)	22 (28.9)	28 (29.5)	49 (23.5)	0.600	0.854 (0.474-1.539)	0.345	1.330 (0.736-2.403)	0.227	1.402 (0.811-2.424)
	AA	6 (5.9)	1 (1.3)	3 (3.1)	2 (1.0)	0.0191	6.280 (1.238-31.854)	1.0001	1.481 (0.132-16.666)	0.1561	3.680 (0.601-22.544)
	HWE	0.01	0.44	0.977	0.391
Recessive model	GG + GA	95 (94.1)	75 (98.7)	92 (96.8)	206 (99.0)		Reference		Reference		Reference
	AA	6 (5.9)	1 (1.3)	3 (3.2)	2 (1.0)	0.0171	6.505 (1.289-32.828)	1.0001	1.373 (0.123-15.367)	0.3301	3.359 (0.552-20.441)
Dominant model	GG	75 (74.3)	53 (69.7)	64 (67.4)	157 (75.5)		Reference		Reference		Reference
	AA + GA	26 (25.7)	23 (30.3)	31 (32.6)	51 (24.5)	0.816	1.067 (0.618-1.843)	0.330	1.336 (0.746-2.392)	0.142	1.491 (0.875-2.540)
rs2221903
Allele frequency	Allele T	172 (85.1)	130 (85.5)	167 (87.9)	373 (89.7)		Reference		Reference		Reference
	Allele C	30 (14.9)	22 (14.5)	23 (12.1)	43 (10.3)	0.105	1.513 (0.918-2.495)	0.172	1.468 (0.846-2.547)	0.517	1.195 (0.697-2.046)
Genotype frequency	TT	71 (70.3)	56 (73.7)	75 (78.9)	167 (80.3)		Reference		Reference		Reference
	TC	30 (29.7)	18 (23.7)	17 (17.9)	39 (18.7)	0.035	1.809 (1.043-3.139)	0.324	1.367 (0.729-2.598)	0.926	0.971 (0.516-1.825)
	CC	0 (0.00)	2 (2.6)	3 (3.2)	2 (1.0)	-2		0.5751	2.982 (0.410-21.668)	0.3301	3.340 (0.547-20.405)
	HWE	0.080	0.705	0.121	0.868
Recessive model	TT + TC	101 (100.0)	74 (97.4)	92 (96.8)	206 (99.0)		Reference		Reference		Reference
	CC	0 (0.0)	2 (2.6)	3 (3.2)	2 (1.0)	-2		0.5771	2.784 (0.385-20.120)	0.3301	3.359 (0.552-20.441)
Dominant model	TT	71 (70.3)	56 (73.7)	75 (78.9)	167 (80.3)		Reference		Reference		Reference
	CC + TC	30 (29.7)	20 (26.3)	20 (21.1)	41 (19.7)	0.052	1.721 (0.996-2.973)	0.232	1.455 (0.787-2.689)	0.787	1.086 (0.596-1.979)
rs907715
Allele frequency	Allele G	115 (56.9)	89 (58.6)	105 (55.3)	234 (56.2)		Reference		Reference		Reference
	Allele A	87 (43.8)	63 (41.4)	85 (44.7)	182 (43.8)	0.873	0.973 (0.693-1.366)	0.624	0.910 (0.625-1.326)	0.820	1.041 (0.737-1.470)
Genotype frequency	GG	33 (32.7)	24 (3.16)	28 (29.5)	70 (33.7)		Reference		Reference		Reference
	GA	49 (48.5)	41 (53.9)	49 (51.6)	94 (45.2)	0.715	1.106 (0.645-1.896)	0.425	1.272 (0.704-2.298)	0.352	1.303 (0.746-2.277)
	AA	19 (18.8)	11 (14.5)	18 (18.9)	44 (21.1)	0.800	0.916 (0.465-1.806)	0.443	0.729 (0.325-1.634)	0.950	1.023 (0.507-2.064)
	HWE	0.914	0.331	0.674	0.238
Recessive model	GG + GA	82 (81.2)	65 (85.5)	77 (81.1)	164 (78.8)		Reference		Reference		Reference
	AA	19 (18.8)	11 (14.5)	18 (18.9)	44 (21.2)	0.632	0.864 (0.474-1.573)	0.210	0.631 (0.307-1.296)	0.659	0.871 (0.473-1.606)
Dominant model	GG	33 (32.7)	24 (31.6)	28 (29.5)	70 (33.7)		Reference		Reference		Reference
	AA + GA	68 (67.3)	52 (68.4)	67 (70.5)	138 (66.3)	0.864	1.045 (0.630-1.733)	0.742	1.099 (0.626-1.929)	0.471	1.214 (0.717-2.055)

¹Fisher’s exact test;

²χ² test cannot be conducted due to cross tabulation of zero. CHB: Chronic hepatitis B; HWE: Hardy-Weinberg equilibrium.