Interleukin-21 gene polymorphisms and chronic hepatitis B infection in a Chinese population

Table 3 Interleukin-21 polymorphisms among chronic hepatitis B virus-infected patients with hepatocellular carcinoma, patients without hepatocellular carcinoma, and controls n (%)

Polymorphism		HCC	non-HCC	Control	HCC vs non-HCC		HCC vs Control		non-HCC vs Control
		(n = 94)	(n = 272)	(n = 208)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)
rs13143866
Allele frequency	Allele G	167 (88.8)	454 (83.5)	363 (87.3)		Reference		Reference		Reference
	Allele A	21 (11.2)	90 (16.5)	53 (12.7)	0.078	1.576 (0.949-2.617)	0.586	0.861 (0.503-1.474)	0.102	1.358 (0.941-1.958)
Genotype frequency1	GG	74 (78.7)	192 (70.6)	157 (75.5)		Reference		Reference		Reference
	GA	19 (20.2)	70 (25.7)	49 (23.5)	0.231	1.420 (0.800-2.520)	0.522	0.823 (0.453-1.495)	0.470	1.168 (0.766-1.781)
	AA	1 (1.1)	10 (3.7)	2 (1.0)	0.2982	3.854 (0.485-30.637)	1.0002	1.061 (0.095-11.886)	0.0741	4.089 (0.883-18.934)
	HWE	0.857	0.262	0.391
Recessive model	GG + GA	93 (98.9)	262 (96.3)	206 (99.0)		Reference		Reference		Reference
	AA	1 (1.1)	10 (3.7)	2 (1.0)	0.2302	0.282 (0.036-2.231)	1.0002	1.108 (0.099-12.367)	0.0771	3.931 (0.852-18.139)
Dominant model	GG	74 (78.7)	192 (70.6)	157 (75.5)		Reference		Reference		Reference
	AA + GA	20 (21.3)	80 (29.4)	51 (24.5)	0.129	1.542 (0.882-2.695)	0.539	0.832 (0.463-1.495)	0.234	1.283 (0.852-1.932)
rs2221903
Allele frequency	Allele T	163 (86.7)	469 (86.2)	373 (89.7)		Reference		Reference		Reference
	Allele C	25 (13.3)	75 (13.8)	43 (10.3)	0.866	1.043 (0.641-1.696)	0.288	1.330 (0.786-2.252)	0.108	1.387 (0.931-2.067)
Genotype frequency1	TT	70 (74.5)	202 (74.3)	167 (80.3)		Reference		Reference		Reference
	TC	23 (24.5)	65 (23.9)	39 (18.7)	0.940	0.979 (0.566-1.694)	0.075	1.668 (0.949-2.932)	0.160	1.378 (0.881-2.154)
	CC	1 (1.1)	5 (1.8)	2 (1.0)	0.6962	1.733 (0.199-15.087)	1.0002	1.193 (0.106-13.369)	0.4661	2.067 (0.396-10.790)
	HWE	0.554	0.931	0.868
Recessive model	TT + TC	93 (98.9)	267 (98.2)	206 (99.0)		Reference		Reference		Reference
	CC	1 (1.1)	5 (1.8)	2 (1.0)	0.6962	1.742 (0.201-15.101)	1.0002	1.108 (0.099-12.367)	0.4791	1.929 (0.700-10.042)
Dominant model	TT	70 (74.5)	202 (74.3)	167 (80.3)		Reference		Reference		Reference
	CC + TC	24 (25.5)	70 (25.7)	41 (19.7)	0.969	0.989 (0.578-1.693)	0.256	1.397 (0.785-2.484)	0.122	1.411 (0.912-2.184)
rs907715
Allele frequency	Allele G	106 (56.4)	309 (56.8)	234 (56.2)		Reference		Reference		Reference
	Allele A	82 (43.6)	235 (43.2)	182 (43.8)	0.920	0.983 (0.704-1.374)	0.976	0.995 (0.703-1.408)	0.864	0.978 (0.756-1.265)
Genotype frequency1	GG	25 (26.6)	85 (31.2)	70 (33.7)		Reference		Reference		Reference
	GA	56 (59.6)	139 (51.1)	94 (45.2)	0.256	0.730 (0.424-1.257)	0.135	0.598 (0.305-1.173)	0.347	1.218 (0.808-1.836)
	AA	13 (13.8)	48 (17.7)	44 (21.1)	0.831	1.086 (0.509-2.317)	0.062	0.827 (0.383-1.785)	0.685	0.898 (0.536-1.507)
	HWE	0.041	0.496	0.238
Recessive model	GG + GA	81 (86.2)	224 (82.4)	164 (78.8)		Reference		Reference		Reference
	AA	13 (13.8)	48 (17.6)	44 (21.2)	0.393	1.335 (0.688-2.592)	0.135	0.598 (0.305-1.173)	0.334	0.799 (0.506-1.260)
Dominant model	GG	25 (26.6)	85 (31.3)	70 (33.7)		Reference		Reference		Reference
	AA + GA	69 (73.4)	187 (68.7)	138 (66.3)	0.397	0.797 (0.472-1.347)	0.222	1.400 (0.816-2.403)	0.577	1.116 (0.759-1.640)

¹The P values of rs13143866, rs2221903, and rs907715 genotype distribution among hepatocellular carcinoma (HCC) group, non-HCC group, and controls were 0.237, 0.876, and 0.358, respectively;

²Fisher’s exact test. HWE: Hardy-Weinberg equilibrium.