Interleukin-21 gene polymorphisms and chronic hepatitis B infection in a Chinese population

Table 2 Comparison of interleukin-21 polymorphisms between chronic hepatitis B virus-infected patients and controls n (%)

Polymorphism		HBV infection (n = 366)	Control (n = 208)	P value	OR (95%CI)
rs13143866
Allele frequency	Allele G	621 (85.5)	363 (87.3)		Reference
	Allele A	111 (14.5)	53 (12.7)	0.259	1.224 (0.861-1.741)
Genotype frequency1	GG	266 (72.7)	157 (75.5)		Reference
	GA	89 (24.3)	49 (23.5)	0.734	0.933 (0.625-1.392)
	AA	11 (3.0)	2 (1.0)	0.2902	0.308 (0.067-1.408)
	HWE	0.294	0.391
Recessive model	GG + GA	355 (97.0)	206 (99.0)		Reference
	AA	11 (3.0)	2 (1.0)	0.1492	3.195 (0.701-14.493)
Dominant model	GG	266 (72.7)	157 (75.5)		Reference
	AA + GA	100 (27.3)	51 (24.5)	0.463	1.157 (0.783-1.711)
rs2221903
Allele frequency	Allele T	632 (86.3)	373 (89.7)		Reference
	Allele C	100 (13.7)	43 (10.3)	0.101	1.373 (0.939-2.006)
Genotype frequency1	TT	272 (74.3)	167 (80.3)		Reference
	TC	88 (24.1)	39 (18.7)	0.130	1.385 (0.907-2.116)
	CC	6 (1.6)	2 (1.0)	0.2622	1.842 (0.367-9.232)
	HWE	0.712	0.868
Recessive model	TT+TC	360 (98.4)	206 (99.0)		Reference
	CC	6 (1.6)	2 (1.0)	0.7172	1.715 (0.342-8.547)
Dominant model	TT	272 (74.3)	167 (80.3)		Reference
	CC + TC	94 (25.7)	41 (19.7)	0.105	1.408 (0.930-2.130)
rs907715
Allele frequency	Allele G	415 (56.7)	234 (56.2)		Reference
	Allele A	317 (43.3)	182 (43.8)	0.884	0.982 (0.770-1.252)
Genotype frequency1	GG	110 (30.0)	70 (33.7)		Reference
	GA	195 (53.3)	94 (45.2)	0.160	1.320 (0.896-1.945)
	AA	61 (16.7)	44 (21.1)	0.155	0.882 (0.540-1.440)
	HWE	0.104	0.238
Recessive model	GG + GA	305 (83.3)	164 (78.8)		Reference
	AA	61 (16.7)	44 (21.2)	0.181	0.746 (0.484-1.148)
Dominant model	GG	110 (30.1)	70 (33.7)		Reference
	AA + GA	256 (69.9)	138 (66.3)	0.372	1.181 (0.820-1.699)

¹The P values of rs13143866, rs2221903, and rs907715 genotype distribution between chronic HBV-infected patients and controls were 0.237, 0.876, 0.358, respectively;

²Fisher’s exact test. HWE: Hardy-Weinberg equilibrium.