Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases

Table 1 Clinical characteristics and family histories of 23 early-onset and familial colorectal cancer patients

Patient ID	Gender	Patient's history	Family history
43-1A	Female	RC at 37 yr	Brother RC at 53 yr
43-2A	Male	RC at 53 yr	Sister RC at 37 yr
49-4A	Male	CC at 30 yr	Brother CC at 43 yr; sister CC at 23 yr
49-5A	Female	CC at 23 yr	Brother CC at 43 yr; brother CC at 30 yr
50-11A	Male	CC at 34 yr and relapse at 36	Father CRC at 35 yr and death at 52 yr; brother CC at 34 yr and death at 36 yr
54-2A	Female	RC at 44 yr	Sister CRC; Brother CC at 76 yr and death
66-1-1A	Female	CC at 47 yr	Sister CC at 51 yr
71A	Female	RC at 57 yr	Sister RC at 53 yr
77-1A	Female	CRC at 38 yr	Father EC at 64 yr and death; uncle CRC at 68 yr and death
102-1A	Male	RC at 25 yr
103-1A	Male	CC at 53 yr	Brother CC at 36 yr and death at 48 yr; mother IO at 63 yr and death
106-2A	Male	JC at 34 yr, CC at 39 yr, KC at 44 yr and PC at 45 yr	Father EC and death; mother RC at 42 yr and death; Sister CP
108-1A	Male	RC at 33 yr
110-1A	Male	CC at 36 yr
116-1A	Female	CC at 31 yr and HC at 57 yr	Brother intussusception and death at 40 yr; Brother CC at 50 yr, RC and SMT at 58 yr; brother IC at 50 yr, CC at 53 yr and RC at 61 yr; sister GC at 56 yr
120-1A	Female	RC at 36 yr
142-1A	Male	RC at 34 yr
149-1A	Male	CRC at 31 yr	Father EC and death, mother GC at 56 yr
154-1A	Female	CRC at 40 yr	Father HC, RC and death at 57 yr
156-1A	Female	CRC at 54 yr	Sister CP at 54 yr; sister CP; mother CC at 48 yr; grandfather EC and death.
164-1A	Male	CC at 30 yr	Uncle colonitls at 42 yr
165-1A	Male	CRC at 43 yr	Sister RC at 31 yr and death; grandmother RC at 65 yr and death.
180-1	Male	CRC at 40 yr	Sister CP at 46 yr

CRC: Colorectal cancer; CC: Colon cancer; RC: Rectal cancer; IC: Ileocecus carcinoma; IO: Intestinal obstruction; JC: Jejunum cancer; KC: Kidney cancer; PC: Pulmonary carcinoma; CP: Colonic polyps; HC: Hepatic carcinoma; GC: Gastric cancer; EC: Esophageal cancer; SMT: Splenic metastatic tumors.