Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma

Figure 3 Methylation levels and receiver operating characteristic curve analysis of IRAK3 and GLOXD1 in liver tissues. A: Gene methylation was determined in 29 normal controls (NC) and 160 paired hepatocellular carcinoma (HCC) tissues and their adjacent notumor tissues (NT) by quantitative methylation-specific polymerase chain reaction. The results are represented as the difference in the methylation index. The black lines indicate the mean of the methylation index. (NC vs HCC, unpaired t-test; NT vs HCC, paired t-test); B: The area under the receiver operating characteristic curve (AUC) for each gene was calculated to discriminate 29 normal individuals and 160 HCC cases.