Caffeic acid phenethyl ester inhibits liver fibrosis in rats

Figure 10 NF-E2-related factor 2 expression in liver tissue (immunohistochemistry). The NF-E2-related factor 2 (Nrf2) expression in liver tissue was confirmed by immunohistochemistry (× 400). A: Liver sections of the normal group showed a small amount of Nrf2-positive cells only present in the cytoplasm; B: Liver sections of the model group showed only a few Nrf2-positive cells present in the fibrous septa and inflamed area; C: Liver sections of the vitamin E group showed that Nrf2-positive cells were distributed in fibroplasia and inflamed area, but the number of positive cells was more than that in the model group; D: Liver sections of the caffeic acid phenethyl ester (12 mg/kg) group showed that Nrf2-positive cells were located mainly in fibrosis and inflamed area and were strongly stained. The results of the other groups are not shown here.