Field cancerisation in colorectal cancer: A new frontier or pastures past?

Figure 2 Changes in crypt morphology, cellular ultrastructure and epigenetic modulation in the field defect. A, B: Changes in crypt morphology characterised by increased branching and distension of crypts, increased cell division and a change in proportion of cells with increase in goblet cells; C, D: Changes in the cell cytoskeleton, organelles and nuclear composition; E, F: Epigenetic modulation of DNA leading to transcriptional silencing of certain genes involved in regulation of cell division, apoptosis and DNA repair.