Gastroenterology case report of mesalazine-induced cardiopulmonary hypersensitivity

Table 2 Summary of previously published cases of mesalazine-induced cardiac hypersensitivity in patients with inflammatory bowel disease

Ref.	Age (yr)/sex	Disease	Daily dose	Duration of therapy	Symptoms	Cardiac disease	Pharmacologic treatment	Rechallenge /recurrence
Vayre et al[51]	53/M	CD	500 mg	8 yr	T, CP	AP, PE	Prednisolone	No
Ishikawa et al[16]	17/M	UC	1.5 g	2 wk	T, CP	AP, PE	Prednisolone	Yes/Yes
Doganay et al[52]	21/M	UC	2 g	10 d	T, D	AM	Budesonide	No
García-Morán et al[17]	39/M	UC	4 g P.O. + 2 g (enemas)	2 d	T, CP	AM, AMI	Methylprednisolone	No
Martín et al[53]	22/M	UC	3 g	ND	CP	AM	Corticosteroids	No
Cappell et al[15]	32/M	UC	ND	10 yr	T, CP, D	Chronic pericarditis, PT	Prednisone	No
Bernal-Sprekelsen et al[54]	54/M	UC	1.5 g	3 wk	T, CP	AP, PE	ASA	Yes/Yes1
Freeman et al[55]	26/M	UC	1.6 g	3 wk	T, CP	AM	Hydrocortisone	Yes/No2
Sierra Ausín et al[56]	47/M	UC	3 g P.O. + 1 g (enemas)	3 wk	T, CP	AP	NSAIDs	No
Park et al[57]	26/M	UC	2.4 g	1 mo	T, CP	AM, PE	ASA, prednisolone	Yes/Yes
Calafat et al[13]	37/M	UC	1 g IR	1 mo	CP	AP, PE	ASA	No
	37/F	UC	3g	2 wk	CP	AP, PE	Analgesics	No
Sonu et al[58]	20/F	UC	Sulfasalazine 2 g + mesalazine (enemas)3	3 wk	CP	AM, PT	Ibuprofen and colchicine	Yes/Yes4
Current case	32/M	UC	1.5-3 g5	14 mo	T, CP, D	AP, PE	Prednisone	No

¹After mesalazine suspension a rechallenge with mesalazine 500 mg IR was intended with recurrence of symptoms;

²After mesalazine suspension a rechallenge with sulfasalazine was intended without recurrence of symptoms;

³Mesalazine dose was not specified;

⁴After both sulfasalazine and mesalazine enemas were suspended, and low-dose balsalazide was initiated with recurrence of symptoms;

⁵Mesalazine dose was increased after patient was admitted. AP: Acute pericarditis; AM: Acute myopericarditis; AMI: Acute mitral insufficiency; ASA: Acetylsalicylic acid; CD: Crohn’s disease; CP: Chest pain; D: Dyspnea; F: Female; IR: Intrarectal; M: Male; ND: No data available; NSAIDs: Nonsteroidal anti-inflammatory drugs; PE: Pericardial effusion; PT: Pericardial tamponade; T: Fever; UC: Ulcerative colitis.