Interferon-λ-related genes and therapeutic response in Chinese hepatitis C patients

Table 4 Polymorphisms of IL28RA/IL28B and rapid viral response n (%)

Genotype	RVR (n = 133)	NRVR (n = 105)	Crude OR (95%CI)	P value	Adjusted OR (95%CI)	P value
rs11249006
AA	51 (38.35)	49 (46.67)	1		1
AG	62 (46.62)	49 (46.67)	1.22 (0.71-2.09)	0.048	0.86 (0.45-1.63)	0.637
GG	20 (15.04)	7 (6.67)	2.75 (1.07-7.07)	0.036	2.33 (0.84-6.48)	0.104
Dominant			1.41 (0.84-2.36)	0.197	1.06 (0.58-1.94)	0.852
Recessive			2.48 (1.01-6.11)	0.049	2.52 (0.96-6.64)	0.061
Additive			1.47 (0.99-2.19)	0.055	1.27 (0.82-1.98)	0.282
rs12980275
AA	118 (88.72)	70 (66.67)	1		1
AG	8 (6.02)	28 (26.67)	0.17 (0.07-0.39)	< 0.001	0.11 (0.04-0.30)	< 0.001
GG	7 (5.26)	7 (6.67)	0.59 (0.20-1.76)	0.347	0.54 (0.17-1.74)	0.301
Dominant			0.25 (0.13-0.50)	< 0.001	0.19 (0.09-0.43)	< 0.001
Recessive			0.78 (0.26-2.29)	0.648	0.82 (0.26-2.56)	0.736
Additive			0.46 (0.28-0.76)	0.002	0.43 (0.24-0.75)	0.003

Logistic regression analyses adjusted for sex, HCV genotype, baseline levels of ALT, WBC, AFP, and viral loads. RVR: Rapid viral response.