Interferon-&lambda;3 polymorphisms in pegylated-interferon-&alpha; plus ribavirin therapy for genotype-2 chronic hepatitis C

doi:10.3748/wjg.v21.i13.3904

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World Journal of Gastroenterology

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World J Gastroenterol. Apr 7, 2015; 21(13): 3904-3911
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3904

Table 1 Analysis of factors affecting rapid virologic response to pegylated interferon-α plus ribavirin combination therapy in patients infected with hepatitis C virus genotype 2

	RVR	non-RVR	RVR vs non-RVR (1: non-RVR/2: RVR)
			Univariate analysis	Multivariate analysis
			P value	OR	95%CI	P value
Baseline factors
Demographic data
Number of patients	111	69
Gender (1:male/2:female)	54/57	31/38	0.8705
Age (yr)	60 (18-76)	60 (18-80)	0.9623
Body weight (kg)	59.4 (35.6-90.9)	56.0 (37.0-104)	0.5154
Body mass index (kg/m²)	23.4 (17.1-31.2)	22.8 (15.2-34.8)	0.9645
Histological fibrosis of liver (F0/1/2/3/4/ND )¹	5/45/18/13/13/17	2/24/9/6/17/11
(F0-3/F4)	81/13	41/17	0.0202
Prior interferon and ribavirin treatment response
Naïve/Relapse/Non response	101/10/0	64/3/2	0.8577
Laboratory data
Genetic variation at rs8099917 (TT/TG or GG)	87/24	55/14	0.9800
HCV-RNA (log₁₀IU/mL)	5.5 (5.0-7.0)	6.4 (5.0-7.3)	< 0.0001	4.40	2.24-8.63 (per 1.0 log₁₀IU/mL)	< 0.0001
HCV Genotype (2a/2b/2a + 2b/ND)	69/23/2/17	29/34/2/4	0.0005
White blood cells (/μL)	4800 (2400-10300)	4700 (2000-10200)	0.5170
Hemoglobin (g/dL)	14.1(9.5-18.2)	13.8 (9.3-16.9)	0.1899
Platelets (× 10⁴/μL)	17.1 (4.8-34.1)	16.6 (5.5-34.1)	0.7993
Aspartate aminotransferase (IU/L)	48 (16-317)	48 (13-455)	0.6753
Alanine aminotransferase (IU/L)	57 (10-361)	56 (9-356)	0.9699
Gamma-glutamyl-transpeptitase (IU/L)	43 (7-719)	48 (9-331)	0.7526
Albumin (g/dL)	4.1 (3.2-5.0)	4.0 (2.9-4.8)	0.0029	0.13	0.04-0.42 (per 1.0 g/dL)	0.0006
Fasting total cholesterol (mg/dL)	170 (118-265)	173 (106-270)	0.8155
Fasting low density lipoprotein-cholesterol (mg/dL)	99 (45-158)	103 (40-181)	0.4186
Fasting plasma glucose (mg/dL)	99 (76-221)	100 (76-320)	0.2002
Homeostasis model assessment-Insulin Resistance	1.59 (0.56-10.83)	1.38 (0.79-6.88)	0.4722
Alpha-fetoprotein (ng/mL)	4.7 (1.6-193.6)	5.0 (1.0-130)	0.4101

¹Classified by METAVIR score. Data are expressed as number of patients or median (range); ND: Not done; HCV: Hepatitis C virus; RVR: Rapid virologic response.

Citation: Ishiguro H, Abe H, Seki N, Sugita T, Aida Y, Itagaki M, Sutoh S, Shimada N, Furihata T, Tsubota A, Aizawa Y. Interferon-λ3 polymorphisms in pegylated-interferon-α plus ribavirin therapy for genotype-2 chronic hepatitis C. World J Gastroenterol 2015; 21(13): 3904-3911
URL: https://www.wjgnet.com/1007-9327/full/v21/i13/3904.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i13.3904