Insulin-like growth factor-1 mRNA isoforms and insulin-like growth factor-1 receptor mRNA expression in chronic hepatitis C

doi:10.3748/wjg.v21.i13.3867

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2015; 21(13): 3867-3875
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3867

Table 3 Values of Spearman’s coefficient for correlation between expression of insulin-like growth factor-1, insulin-like growth factor-1R mRNAs, and clinical data in hepatitis C virus-infected patients

	Class 1 (P1)	Class 2 (P2)	IGF-1A	IGF-1B	IGF-1C	Total IGF-1	IGF-1R
Age (yr)	-0.545¹	-0.644¹	-0.582¹	-0.654¹	-0.532¹	-0.596¹	0.372¹
BMI	-0.527¹	-0.452¹	-0.468¹	-0.414¹	-0.489¹	-0.468¹	0.060
Grading	-0.431¹	-0.569¹	-0.446¹	-0.430¹	-0.285¹	-0.457¹	0.456¹
Staging	-0.223	-0.346¹	-0.182	-0.187	-0.160	-0.190	0.264
Steatosis (%)	-0.415¹	-0.571¹	-0.412¹	-0.408¹	-0.454¹	-0.422¹	0.125
ALT (U/L)	-0.538¹	-0.616¹	-0.540¹	-0.577¹	-0.533¹	-0.550¹	0.181
AST (U/L)	-0.434¹	-0.569¹	-0.378¹	-0.400¹	-0.342¹	-0.392¹	0.212
AFP (ng/mL)	-0.291	-0.390¹	-0.168	-0.271	-0.240	-0.180	0.311
HCV RNA (IU/mL)	-0.330	-0.388¹	-0.357¹	-0.244	-0.096	-0.345¹	0.403¹
Total protein (g/dL)	0.302	0.251	0.324	0.375¹	0.366¹	0.319	0.141
Albumins (g/dL)	0.293	0.381¹	0.303	0.349¹	0.222	0.295	0.123
Gamma globulins (g/dL)	-0.061	-0.164	0.039	0.045	0.174	0.044	0.138
Blood platelets (G/L)	0.273	0.372¹	0.235	0.265	0.138	0.232	-0.099
Cholesterol (mg/dL)	0.386¹	0.286	0.409¹	0.405¹	0.372	0.404¹	0.048
GGTP (U/L)	-0.384	-0.603¹	-0.284	-0.399	-0.367	-0.307	0.330
Blood glucose (mg/dL)	-0.083	-0.226	-0.190	-0.112	-0.084	-0.201	0.152
HOMA-IR	-0.067	-0.157	-0.237	-0.140	-0.184	-0.234	-0.019
Insulin (μU/mL)	-0.020	-0.082	-0.145	-0.079	-0.125	-0.135	-0.045

¹The numbers indicate values of r coefficient for which the P < 0.05. IGF-1: Insulin-like growth factor 1; HCV: Hepatitis C virus; AFP: Alpha fetoprotein.

Citation: Kasprzak A, Adamek A, Przybyszewska W, Pyda P, Szmeja J, Seraszek-Jaros A, Lanzafame A, Surdacka A, Mozer-Lisewska I, Koczorowska M. Insulin-like growth factor-1 mRNA isoforms and insulin-like growth factor-1 receptor mRNA expression in chronic hepatitis C. World J Gastroenterol 2015; 21(13): 3867-3875
URL: https://www.wjgnet.com/1007-9327/full/v21/i13/3867.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i13.3867