Adjuvant therapy for gastric cancer: What have we learned since INT0116?

doi:10.3748/wjg.v21.i13.3850

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2015; 21(13): 3850-3859
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3850

Table 3 Randomized clinical trials comparing perioperative chemotherapy vs observation

Study	Treatment	n	D	DFS	OS	Toxicities G3-G4
MAGIC[28]	ECF vs observation	503	D1-2	0.66 (0.53-0.81)^a	0.75 (0.60-0.93)^a	Leuco 27.8%, N 12.3%
ACCORD-07[30]	CF vs observation	224	NR	0.65 (0.48-0.89)^a	0.69 (0.50-0.95)^a	Leuco 20.2%, N 9.2%

^aP < 0.05, perioperative chemotherapy vs observation. D: Lymphadenectomy; DFS: Disease-free survival; OS: Overall survival; XELOX: Capecitabine + Oxaliplatin; N: Nausea; Leuco: Leucopenia; NR: Not reported.

Citation: Jácome AA, Sankarankutty AK, dos Santos JS. Adjuvant therapy for gastric cancer: What have we learned since INT0116? World J Gastroenterol 2015; 21(13): 3850-3859
URL: https://www.wjgnet.com/1007-9327/full/v21/i13/3850.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i13.3850