Gastrointestinal Behçet's disease: A review

Table 2 Differences between intestinal Behçet’s disease and Crohn’s disease[39,40,48,49,52,54]

	Crohn’s disease	Intestinal BD
Extra-intestinal manifestations	Iritis, episcleritis more specific	Oral and genital ulcers more common, papulopustular lesions, neurologic and arterial manifestations
Perianal disease (fistula, fissures)	Common	Rare
Strictures, fistula, abscess	Common, characteristic of disease process	Less common but possible
Serologic markers	Anti-saccharomyces cerevisiae antibody (Prevalence: 41%-76%)	IgM anti-α-enolase antibody (Prevalence: 67.5%)
Endoscopic features	Irregular, longitudinal ulcers with cobblestone appearance, may have aphthous lesions Segmental or diffuse involvement	Round or oval shaped, punched-out lesions with discrete margins, > 1 cm, Focal distribution, < 5 ulcers. No aphthous lesions
Pathognomonic lesions on histopathology	Non-caseating epithelioid granuloma	Non-specific neutrophilic or lymphocytic phlebitis with or without aortitis

BD: Behçet’s disease.