Hepatitis C virus and antiviral innate immunity: Who wins at tug-of-war?

doi:10.3748/wjg.v21.i13.3786

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 21, Issue 13

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (11423)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-2) series, Tables (1-1) series.

Item

Count

PDF

692

WORD

312

HTML

7070

Figures (1-2)

375

Tables (1-1)

196

Sum=8645

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1215

Download

1563

Sum=2778

Apr 7, 2015 (publication date) through Nov 15, 2024

Times Cited of This Article

Times Cited (23)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Topic Highlight

World J Gastroenterol. Apr 7, 2015; 21(13): 3786-3800
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3786

Table 1 Antiviral interferon-stimulated genes targeting different steps of the hepatitis C virus life cycle

Gene symbol	Phases of HCV life cycle targeted by ISGs	Infection or replicon for studies	Overexpression or knockdown of ISGs for tests	Ref.
IFITM1	Entry	Infection	oe/kd	[158]
	Replication	Infection	oe/kd	[159]
	Replication	Replicon	kd	[147]
IFITM3	Translation	Replicon	oe	[161]
	Replication	Replicon	oe	[160]
	Replication	Replicon	oe/kd	[147]
DDIT4	Translation	Infection/replicon	oe	[144]
IFI44L	Translation	Infection/replicon	oe	[144]
IRF1	Translation	Infection/replicon	oe	[144]
IRF1	Replication	Replicon	oe	[162]
IRF2	Translation	Infection/replicon	oe	[144]
IRF7	Translation	Infection/replicon	oe	[144]
MAP3K14	Translation	Infection/replicon	oe	[144]
MDA5	Translation	Infection/replicon	oe	[144]
NT5C3	Translation	Infection/replicon	oe	[144]
RIG-I	Translation	Infection/replicon	oe	[144]
OASL	Translation	Infection	oe	[144]
OASL	Replication	Replicon	oe	[152]
RNaseL	Replication	Replicon	oe/kd	[147]
RNaseL	Replication	Infection	oe	[153]
ADAR1	Replication	Replicon	kd	[163]
GBP-1	Replication	Replicon	oe/kd	[162]
IFI27	Replication	Replicon	oe/kd	[162]
IFI6	Replication	Replicon	oe/kd	[162]
IFIT1	Replication	Infection	oe/kd	[162]
IFIT3	Replication	Replicon	kd	[147]
IRF9	Replication	Replicon	oe	[162]
ISG20	Replication	Replicon	oe	[164]
MxA	Replication	Replicon	oe	[162]
NOS2	Replication	Replicon	oe/kd	[147]
OAS	Replication	Replicon	oe	[162]
PLSCR1	Replication	Replicon	oe/kd	[147]
TRIM14	Replication	Replicon	oe/kd	[147]
Viperin	Replication	Replicon	oe	[164]
	Replication	Replicon	oe	[165]
	Replication	Infection/replicon	oe	[155]
	Replication	Infection	kd	[156]
Tetherin	Release	Infection	oe	[166]

HCV: Hepatitis C virus; ISGs: Interferon-stimulated genes; Infection or replicon: The functions of ISGs were studied by using infectious culture system (infection) or subgenomic replicon (replicon); oe or kd: The functions of ISGs were identified by using overexpression (oe) or knockdown (kd) of indicated ISGs in cells.

Citation: Yang DR, Zhu HZ. Hepatitis C virus and antiviral innate immunity: Who wins at tug-of-war? World J Gastroenterol 2015; 21(13): 3786-3800
URL: https://www.wjgnet.com/1007-9327/full/v21/i13/3786.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i13.3786