Effect of entacapone on colon motility and ion transport in a rat model of Parkinson’s disease

Figure 5 cAMP pathway involved in entacapone-induced Cl^-secretion in 6-OHDA Parkinson’s disease rats. A: Representation of effects of MDL 12330A (20 μmol/L) on entacapone (ENT)-induced I_SC changes; B: Generalization of I_SC caused by ENT after treatment by MDL 12330A; C: Generalization of the roles of indomethacin (INDO) on intracellular cAMP content caused by ENT in 6-OHDA Parkinson’s disease (PD) rats; D: Generalization of the roles of INDO on intracellular cGMP content caused by ENT in 6-OHDA PD rats (n = 6,^aP < 0.05 vs control).