Effect of entacapone on colon motility and ion transport in a rat model of Parkinson’s disease

Figure 3 Entacapone-induced I_SC response in colonic mucosa specimens in 6-OHDA Parkinson’s disease rats. A: The short circuit current (I_SC) changes induced by apical and basolateral using of ENT (200 μmol L^-1); B: Basolateral application of ENT (200 μmol/L) induced transepithelial electric resistance (n = 13); C: Effect of indomethacin (INDO) (10 μmol/L) on the entacapone (ENT)-caused I_SC changes with 6-OHDA PD rats (n = 9); D: Summary of the effects of pretreatment by removing Cl^- from the extracellular fluid, the apical use of DPC (1 mmol/L) (a type of Cl^-channel inhibitor), and the basolateral use of Na⁺-K⁺-2Cl^- co-transporter (NKCC) antagonist bumetanide (100 μmol/L) on the ENT-caused I_SC changes in mucosal preparations of colon in 6-OHDA PD rats (n = 9, ^aP < 0.05, ^bP < 0.01 vs control).