Effects of neutrophil elastase inhibitor in patients undergoing esophagectomy: A systematic review and meta-analysis

Table 3 Quality assessment of the included trials

Ref.	Type	Randomization	Blinding	Allocation concealment	Eligibility criteria	Baseline comparability	> 85% participants followed up	ITT analysis	Selective reporting	Incomplete outcome	Other bias
Sato et al[19]	RCT	M	U	U	Y	Y	Y	Y	U	N	U
Akamoto et al[20]	RCT	Y	Y, single blinding	U	Y	Y	Y	Y	U	N	U
Kawahara et al[22]	RCT	M	M, double blinding	U	Y	Y	Y	Y	U	N	U
Makino et al[24]	RCT	Y	Y, triple blinding	Y	Y	Y	Y	Y	U	N	U
Yamaguchi et al[29]	RCT	M	U	U	Y	Y	Y	Y	U	U	U
Iwahashi et al[21]	non-RCT	N	U	U	Y	Y	Y	N	U	N	U
Yamaki et al[30]	non-RCT	N	N	N	M	Y	Y	U	U	N	U
Ono et al[28]	non-RCT	N	N	N	Y	Y	Y	Y	U	N	U
Suda et al[14]	non-RCT	N	N	N	Y	Y	Y	Y	U	N	U
Kobayashi et al[23]	non-RCT	N	N	N	Y	Y	Y	Y	N	N	U
Mimatsu et al[25]	non-RCT	N	N	N	Y	Y	Y	Y	N	N	U
Nishiyama et al[27]	non-RCT	N	N	N	Y	Y	Y	Y	N	N	U
Nagai et al[26]	non-RCT	N	N	N	M	Y	Y	Y	U	N	U

M: Mentioned (the study just mentioned the item but without detailed description); Y: Yes (the study mentioned and detailed the item); N: No (the study did not report the item); U: Unclear.