Effects of neutrophil elastase inhibitor in patients undergoing esophagectomy: A systematic review and meta-analysis

Table 1 Basic characteristics of the included studies

Ref.	Year	Arm	Case (n)	Sex (M/F)	Age (yr)	Usage of sivelestat
Sato et al[19]	2001	SSH	8	-	63.9 ± 6.9	150000 U diluted in 20 mL normal saline every 12 h from operation to POD 5
		Saline	8	-	64.6 ± 8.7
Akamoto et al[20]	2007	SSH	6	5/1	70.8 ± 5.5	4.8 mg/kg per day of sivelestat + 240 mL saline from operation to POD 3
		Saline	7	5/2	65.7 ± 2.9
Kawahara et al[22]	2010	SSH	10	7/3	64 (50-78)1	300 mg/d of sivelestat + 200 mL saline from operation to POD 3
		Saline	10	10/0	63 (65-69)
Makino et al[24]	2011	SSH	16	12/4	65 (61-68)2	4.8 mg/kg per day of sivelestat + 240 mL saline from operation to POD 7
		Saline	15	13/2	66 (63-69)
Yamaguchi et al[29]	2011	SSH	12	9/3	59 ± 5	0.2 mg/kg per hour sivelestat from operation to POD 1
		Saline	12	9/3	60 ± 8
Iwahashi et al[21]	2011	Arm1	15	13/2	65 ± 8	Arm1: 0.2 mg/kg per hour sivelestat from operation to POD 1;
		Arm2	15	9/6	64 ± 7	Arm 2: 0.2 mg/kg per hour sivelestat from operation to POD 5
		Control	15	10/5	67 ± 8	0.2 mg/kg per hour sivelestat
Yamaki et al[30]	2005	SSH	9	-	62 ± 9
		Control	6	-	69 ± 8	0.2 mg/kg per hour sivelestat after operation till POD 5
Ono et al[28]	2007	SSH	7	4/3	61 ± 12
		Control	10	7/3	70 ± 7	0.2 mg/kg per hour sivelestat diluted with saline after operation till POD 6
Suda et al[14]	2007	SSH	18	15/3	60 (55-65)3
		Control	25	20/5	56 (52-66)	0.2 mg/kg per hour from operation and during mechanical ventilation support
Kobayashi et al[23]	2010	SSH	60	56/4	66 ± 7
		Control	28	24/4	60 ± 10	0.2 mg/kg per hour sivelestat diluted with saline after operation till POD 5
Mimatsu et al[25]	2011	SSH	22	21/1	59 ± 11
		Control	20	19/1	63 ± 9	0.2 mg/kg per hour sivelestat after operation till POD 3
Nishiyama et al[27]	2012	SSH	26	23/3	67 ± 8
		Control	27	23/4	63 ± 8	0.2 mg/kg per hour sivelestat with 5% dextrose in water from operation till POD 3
Nagai et al[26]	2013	SSH	42	39/3	66 ± 9
		Control	35	31/4	63 ± 8

¹Range;

²95%CI;

³Inter-quartile range. SSH: Sivelestat sodium hydrate; POD: Postoperative day; Age is shown as mean ± SD.