Cholecystectomy and the risk of alimentary tract cancers: A systematic review

Table 8 Descriptive characteristics of studies on the association between cholecystectomy and small intestinal cancer

Ref.	Period of study	Study design	No. of cases	No. of controls	Exposure ascertainment	Outcome ascertainment	Follow-up (yr)	Effect estimate	Adjustments	Quality of publication
Nogueira et al[21], 2014	1992-2005	Case-control	148/3694	2572/100000	Medicare database	Cancer registry	> 6	OR = 1.49 (1.26-1.77)	Age, gender	49
Lagergren et al[51], 2001	1965-1997	Cohort	68/2784601	NA	National registry	National registry	10	1.77 (1.37-2.24)	Age, gender, time aftercholecystectomy	38
Lagergren et al[51], 2001	1965-1997	Cohort	98/2784602	NA	National registry	National registry	10	1.71 (1.39-2.08)	Age, gender, time aftercholecystectomy	38
Goldacre et al[52], 2012	1998-2008	Cohort	NA	327460/3M	HES database	Cancer registry	10	2.47 (0.82-6.28)	Age, gender, period since cholecystectomy	45

¹Proximal small bowel adenocarcinoma;

²Distal small bowel carcinoids. NA: Not available.