MicroRNA-1290 promotes esophageal squamous cell carcinoma cell proliferation and metastasis

Figure 6 Suppressor of cancer cell invasion is a direct target of miR-1290. A: Putative miR-1290 binding sequence in the 3′-UTR of the mRNA of SCAI is shown; B: Inverse correlation between miR-1290 and mRNA levels of SCAI in tissue samples was illustrated; C: Dual-luciferase reporter assay showed a significant decrease in the relative luciferase activity of wt-SCAI (wild-type SCAI 3′-UTR) co-transfected with miR-1290 mimic compared with that of mut-SCAI (mutant-type SCAI 3′-UTR; ^bP < 0.01 vs control) in Eca109 cells. SCAI: Suppressor of cancer cell invasion.