Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents

Table 3 Clinical characteristics of patients developing active tuberculosis infection after anti-TNF agent

No.	IBD	Sex	Age of anti-TNFs (yr)	Anti-TNFs	Previous TB treatment	Screening IGRA	Screening TST	IS at screening	Prophylaxis	Interval to TB infection (wk)	IS at TB diagnosis	Extra-pulmonary TB	No. of involvement organ
1	CD	F	21	IFX	No	ND	ND	None	ND	83	CS + AZA	No	1
2	CD	M	24	ADA	No	+	ND	CS	INH	22	None	Yes	1
3	CD	M	24	IFX	No	-	ND	CS +AZA	ND	35	AZA	Yes	3
4	CD	M	42	IFX	Yes	-	ND	CS	ND	46	CS + AZA	Yes	6
5	CD	F	34	IFX	Yes	-	ND	AZA	ND	23	AZA	Yes	1
6	CD	M	29	IFX	No	-	ND	AZA	ND	10	AZA	Yes	5
7	CD	M	41	IFX	No	ND	-	AZA	ND	12	AZA	Yes	1
81	CD	M	24	IFX	No	ND	-	CS	ND	8	CS	Yes	4
9	CD	M	27	IFX	No	ND	-	AZA	ND	22	AZA	No	1
10	CD	M	23	IFX	Yes	+	-	AZA	ND	8	CS + AZA	Yes	1
11	CD	M	21	IFX	No	-	Unknown	CS +AZA	ND	129	CS + AZA	Yes	3
12	UC	M	32	IFX	No	+	ND	AZA	INH + RFP	40	AZA	Yes	4
13	UC	M	70	IFX	No	-	ND	AZA	ND	142	AZA	No	1
14	UC	M	21	IFX	No	-	ND	CS +AZA	ND	52	AZA	Yes	3
15	UC	M	56	IFX	No	-	ND	AZA	ND	47	AZA	Yes	2
16	UC	F	25	IFX	No	+	-	AZA	ND	12	AZA	Yes	2

¹This patient died 55 d after miliary tuberculosis diagnosis due to devastating acute renal failure. IBD: Inflammatory bowel disease; CD: Crohn’s disease; UC: Ulcerative colitis; IFX: Infliximab; ADA: Adalimumab; ND: Not done; TB: Tuberculosis; IGRA: Interferon gamma release assay; TST: Tuberculin skin test; IS: Immunosuppressant; CS: Corticosteroid; AZA: Azathioprine; INH: Isoniazid; RFP: Rifampin.