Ratio of metastatic lymph nodes is more important for rectal cancer patients treated with preoperative chemoradiotherapy

Table 4 Factors associated with recurrence-free survival: Multivariate analysis

Factor	No PCRT			PCRT
	HR	95%CI	P value	HR	95%CI	P value
p/yp N category			< 0.001			0.380
N1	1.00			1.00
N2	1.90	1.43-2.53		1.21	0.79-1.85
LNR category			< 0.001			0.001
LNR1	1.00			1.00
LNR2	1.97	1.48-2.63		1.94	1.31-2.88
Lymphovascular invasion			0.34
None	1.00			1.00		0.110
Present	1.24	0.93-1.67		1.42	0.89-2.27
Perineural invasion			0.04			0.030
None	1.00			1.00
Undetermined	1.65	1.12-2.43		1.86	1.18-2.93
Location			0.02			0.040
6-10 cm	1.00			1.00
≤ 5 cm	1.34	1.05-1.85		0.62	0.40-0.98
Preoperative CEA			0.02
Normal	1.00
Increased	1.46	1.07-1.98

PCRT: Preoperative chemoradiotherapy; LNR: Lymph node ratio; CEA: Carcinoembryoinc antigen.