Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R

Figure 3 miR-133a represses the growth of gastric cancer cells in vivo. A: Expression level of miR-133a in stable P2GM-miR-133a cells and empty vector-carrying control stable cells (^bP < 0.01 vs control); B: Stable cells (1000) carrying either P2GM-miR-133a or an empty vector were plated onto six-well plates, and a colony formation assay was carried out; C: Quantitative analysis of colony numbers (^aP < 0.05, ^bP < 0.01 vs control); D: Stable SGC-7901 cells carrying either P2GM-miR-133a or an empty vector were inoculated subcutaneously into the flanks of nude mice (n = 5 per group); E: Representative graphs of tumor masses harvested from nude mice 24 d after inoculation are shown; F: Tumor weight (^aP < 0.05 vs control); G: Growth curves of the tumor volume (^bP < 0.01 vs control). The average tumor weight is indicated as the mean ± SEM.