Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R

Figure 1 Decreased expression levels of miR-133a in gastric cancer tissues and cell lines. A: Expression level of miR-133a in 105 pairs of gastric cancer (GC) tissue samples (tumor) and matched adjacent non-tumor tissue samples (normal) was analyzed using real-time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). U6 snRNA was used as an endogenous control. miR-133a expression was reduced in 80% of the paired tumor samples; B: Expression levels of miR-133a were drastically downregulated in GC tissues compared with the matched adjacent non-tumor tissues (^bP < 0.01 vs non-tumor tissues); C: Relative expression of miR-133a in four GC cell lines and a normal gastric cell line (GES-1). qRT-PCR results represent the mean ± SEM of three independent experiments (^dP < 0.01, ^bP < 0.01 vs GES-1).