Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis

Table 1 Baseline clinical and laboratory characteristics of study population

	All patients (n = 40)	CP A (n = 18)	CP B (n = 10)	CP C (n = 12)	P value1
Sex (M/F), n (%)	35/5 (87.5/12.5)	16/2 (88.9/11.1)	9/1 (90/10)	10/2 (83.3/16.7)	0.870
Age, median years (range)	59 (37-75)	59.5 (43-75)	60.5 (37-71)	59 (45-70)	0.838
Smoking, n (%)	15 (37.5)	7 (38.9)	3 (30)	5 (41.7)	0.954
HCC, n (%)	5 (12.5)	1 (5.6)	1 (10)	3 (25)	0.277
Hemoglobin (11.8-17 g/dL)	12.35 (9.3-16.6)	14.3 (9.8-16.6)	12.75 (10.2-15.1)	10.1 (9.3-13.2)	0.002
WBC count (4 × 109/L-11 × 109/L)	5.888 (3.2-15.18)	6.66 (3.2-12.97)	5.31 (4.1-8.97)	5.66 (4.15-15.18)	0.093
Platelet count (150 × 109/L-400 × 109/L)	113 (81-246)	148 (87-246)	117.5 (70-198)	127 (75-218)	0.306
INR (1-1.3)	1.28 (0.87-2.32)	1.09 (0.87-1.59)	1.2 (1.07-1.92)	1.58 (1.24-2.32)	0.001
PT (s)	15.25 (9.8-24.8)	11.9 (9.8-18.3)	15.15 (12.2-17)	18.6 (15.2-24.8)	< 0.001
Total bilirubin (0.1-1.3 mg/dL)	1.1 (0.28-8.6)	0.72 (0.28-1.19)	1.23 (0.85-3.5)	2.4 (1.6-8.6)	< 0.001
Albumin (3.5-5.5 g/dL)	3.65 (0.9-4.6)	4 (3.4-4.6)	3.6 (2.6-4.3)	2.8 (0.9-3.2)	< 0.001
Creatinine (0.9-1.6 mg/dL)	0.82 (0.68-1.8)	0.88 (0.7-1.7)	0.82 (0.7-1.4)	0.8 (0.68-1.8)	0.967
Urea (15-54 mg/dL)	28 (16-110)	28 (18-64)	26.5 (21-47)	29 (16-110)	0.981
SGOT (5-40 U/L)	36 (15-149)	32.3 (15-48)	59 (24-149)	58 (18-128)	0.017
SGPT (5-40 U/L)	33 (8-156)	32 (8-60)	46 (23-156)	32 (11-64)	0.298
ALP (U/L)	116 (37-303)	104 (41-236)	113.5 (75-244)	123 (37-303)	0.324
GGT (U/L)	94 (12-328)	82.5 (12-231)	135 (61-328)	108 (28-199)	0.057
Glucose (75-115 mg/dL)	99 (60-126)	99 (71-126)	105 (94-126)	92 (60-118)	0.170
Serum sodium (134-152 mmol/L)	138 (129-146)	140.8 (134.5-146)	137.4 (135-141)	135 (129-142)	0.012
Cholesterol (mg/dL)	146 (66-341)	188.5 (130-341)	133 (91-173)	146 (66-168)	0.041
Triglycerides (mg/dL)	88.5 (43-142)	106 (43-142)	74.5 (47-139)	76 (46-116)	0.525
Child-Pugh score (range)	7 (5-12)	NA	NA	NA	NA
MELD score (range)	10 (6-25)	7 (6-16)	11 (8-18)	18 (13-25)	< 0.001
Ascites, n (%)	14 (35)	0	4 (40)	10 (83.3)	< 0.001
Encephalopathy, n (%)	2 (5)	1 (5.6)	0	1 (8.3)	0.664

¹P value: correlation of variables regarding different stages of liver disease. CP: Child-Pugh; HCC: Hepatocellular carcinoma; WBC: White blood cells; INR: International normalized ratio; PT: Prothrombin time; SGOT: Aspartate aminotransferase; SGPT: Alanine aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl-transferase; MELD: Model for End-stage Liver Disease; BMI: Body mass index; NA: Not applicable.