p53 mutations in colorectal cancer- molecular pathogenesis and pharmacological reactivation

Figure 3 Small molecule compounds pharmacologically reactivating of p53 function. MI43 and Nutlin-3 bound to MDM2 blocking MDM2-p53 interaction. RITA bound to p53 interfering MDM2-p53 interaction. α-Lipoic acid increased p53 protein stability and its apoptotic effect. Quinacrine induced the autophagy-associated cell death in a p53-dependent manner. NSC17632 activated p53-like activatity dependent on p73. PRIMA-1/PRIMA-1^MET restored mutant p53 to exert apoptotic effect. Maslinic acid and Epicatechin gallate as plant extraction modulated the expression of p53 and its target genes in p53-dependent apoptotic and cell cycle arrest pathway.