p53 mutations in colorectal cancer- molecular pathogenesis and pharmacological reactivation

Figure 1 Structure and function of p53 tumor suppressor. A: Schematic of p53 protein structure. The function domains and corresponding amino acid regions are indicated. N-terminus transcription-activation domain (TAD): Residues 1-63; AD1: Residues 1-42 for G1 arrest and apoptotic activity; AD2: Residues 43-63 important for senescence-activity; PD: Residues 64-92 important for apoptotic activity; DBD: Residues 102-292 responsible for binding the p53 co-repressors; NLSD: Residues 316-324, 370-376, 380-386; OD: Residues 325-356; NESD: Residues 340-353; B: In normal cells, p53 activates a plethora of target genes involved in diverse biological processes in response to cellular stress. Ub: Ubiquitin; PD: Poly-proline domain; DBD: DNA binding core domain; OD: Homo-oligomerization domain; NESD: Nuclear export signaling domain; NLSD: Nuclear localization signaling domain.