Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker

Figure 1 Circulating metastasis associated in colon cancer 1 transcript levels in plasma discriminate gastric cancer patients from tumor-free volunteers. Levels of circulating metastasis associated in colon cancer 1 (MACC1) transcripts in plasma of all gastric cancer patients (n = 76) were significantly higher than in tumor-free volunteers (n = 54; P < 0.001). All patient subcohorts demonstrated significantly higher levels of circulating MACC1 transcripts when compared to the tumor-free volunteers: patients in stages I to IV (M0) (P = 0.005), patients in stage IV (M1) (P = 0.002), patients with metachronous metastasis (P = 0.005), and patients during follow-up (P = 0.021). Box plot analysis based on quantitative real-time RT-PCR.