FoxM1 overexpression promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma

Figure 2 Forkhead box protein M1 overexpression negatively correlates with E-cadherin expression in hepatocellular carcinoma. A: Forkhead box protein M1 (FoxM1) expression was negatively correlated with E-cadherin expression in hepatocellular carcinoma (HCC) tissues. Representative immunohistochemical images are shown (P < 0.05); B and C: Kaplan-Meier analysis of the correlation between E-cadherin expression and the recurrence or overall survival of HCC patients (P < 0.05); D: Western blot analysis of E-cadherin expression in human HCC cell lines (^aP < 0.05 vs HepG2; ^cP < 0.05 vs SK-Hep1; ^eP < 0.05 vs MHCC-97H); E: Quantitative real-time polymerase chain reaction analysis of E-cadherin mRNA expression in human HCC cell lines (^aP < 0.05 vs HepG2; ^cP < 0.05 vs SK-Hep1; ^eP < 0.05 vs MHCC-97H). Glyceraldehyde-3-phospate dehydrogenase mRNA was used for normalization.