Radiation therapy has been shown to be adaptable for various stages of hepatocellular carcinoma

Table 2 Stereotactic body radiation therapy in hepatocellular carcionoma

Ref.	Patient number	Tumor	Back ground	Median tumor volume	Median dose (Gy)	Fraction	Follow up (mo)	Local control	Overall survival	Adverse effectAcute toxicity grade≥3Late toxicity grade≥3
Andolino et al[42]	60	HCC	LC (CP-A: 36, CP-B: 24)	3.2 cm	44	3	27	2 yr local control 90%	2 yr OS 67%	0%
										N/A
Choi et al[44]	20	HCC	LC (CP-A: 15, CP-B: 5), PVTT: 4	2-6.5 (3.8 cm)	50	5-10	3-55		1 yr OS 70%	0%
							-23		2 yr sOS 43.1%	N/A
Goodman et al[45]	26	meta	meta: 19, CCC: 5, HCC: 4	0.8-146.6 (32.6 cc)	22.5-46.6	1	2-55		1 yr OS 64.3%	0%
		CCC			-34.8		-17		2 yr OS 50.4%	N/A
		HCC
Huang et al[46]	36	HCC	LC (CP-A: 28, CP-B: 7, CP-C: 1)	1.1-12.3 (4.4 cm)	25-48	4-5	14	1 yr in-field failure free rate 87.6%	2 yr OS 72.6%	2.8% (1: gastric ulcer)
					-37			2 yr in-field failure free rate 75.1%		N/A
Kwon et al[47]	42	HCC	LC (CP-A: 38, CP-B: 4, CP-C: 0)	15.4-81.8 (15.4 cc)	30-39	3	8.4-49.1	1 yr in-field progression-free survival rate 72.0%	1 yr OS 72%	0%
							-28.7	3 yr in-field progression-free survival rate 68.0%	3 yr OS 67.5%	1% (1:liver failure)
Louis et al[36]	25	HCC	LC (CP-A: 22, CP-B: 3)	1.8-10.0 (4.5 cm)	45	3	1-24	1 yr local control rate 95%	1 yr OS 79%	4% (1: hepatic/epgastric pain)
							-12.7		2 yr OS 52%	10% (1: gastro duodenal ulcer,
										1: hepatic toxicity)
Méndez Romero et al[48]	25	meta	meta: 17, HCC: 8	0.5-7.2	25-37.5	3-5	0.5-31	1 yr local control rate 94%	1 yr OS 82%	16% (1: pateient died in a hepatic tixicity and bleeding from varices.
		HCC		(3.2 cm)			-12.9	2 yr local control rate 82%	2 yr OS 54%	3: hepatic toxicity.)
										0%
Takeda et al[50]	16	HCC	LC (CP-A: 14, CP-B: 2)	3.4-72 (13.6 cm3)	35-50	5-7 (6)	8.1-33.1	1 yr local control rate 90% <	All patients were alive	0%
							-20.4			0%
Tse et al[51]	41	HCC	HCC (CP-A: 31), CCC (10)	9-1913	24-54	6	10.8-39.2 (17.6)	1 yr in-field local control rate 65%	1 yr OS 51%	43% (13: hepatic toxicity, 1: hemato toxicity, 1: lethargy, 3 : nausea)
		CCC		(173 mL)	-36					6% (1: GI bleeding, 1: bowel obstruction)

HCC: Hepatocellular carcinoma; LC: Local control; CP: Child-Pugh.