p53 mutations in colorectal cancer- molecular pathogenesis and pharmacological reactivation

Table 1 Common, high frequency of p53 missense alterations in colorectal cancer

Exon	Codon	Codon change	Nucleotide change	Amino acid change
5	175	CGC→CAC	G→A	Arg→His
7	245	GGC→AGC	G→A	Gly→Ser
7	245	GGC→GAC	G→A	Gly→Asp
7	248	CGG→TGG	C→T	Arg→Trp
7	248	CGG→CAG	G→A	Arg→Gln
8	273	CGT→TGT	C→T	Arg→Cys
8	273	CGT→CAT	G→A	Arg→His
8	282	CGG→TGG	C→T	Arg→Trp

Data selected from UMD TP53 mutation database (http://p53.fr).