Autoimmune hepatitis, one disease with many faces: Etiopathogenetic, clinico-laboratory and histological characteristics

doi:10.3748/wjg.v21.i1.60

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 21, Issue 1

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (17103)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-4) series, Tables (1-5) series.

Item

Count

PDF

1626

WORD

378

HTML

11851

Figures (1-4)

381

Tables (1-5)

227

Sum=14463

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1108

Download

1532

Sum=2640

Jan 7, 2015 (publication date) through Dec 26, 2024

Times Cited of This Article

Times Cited (133)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Gastroenterol. Jan 7, 2015; 21(1): 60-83
Published online Jan 7, 2015. doi: 10.3748/wjg.v21.i1.60

Table 4 Subdivision of autoimmune hepatitis according to the autoantibodies detected

Types of AIH	Characteristic autoantibodies
AIH-1	ANA, SMA, p-ANCA (p-ANNA), anti-ASGP-R, anti-SLA/LP (specific antibody; molecular target: SepSecS)
AIH-2	Anti-LKM1 (molecular target: CYP2D6), anti-LKM3 (molecular target: UGT1), anti-LC1 (liver specific antibody, molecular target: FTCD), anti-ASGP-R
AIH as component of APECED	ANA, anti-LC (molecular target: unknown), anti-LKM (molecular target: CYP2A6, CYP1A1, CYP2B6), anti-LM (liver specific antibody; molecular target: CYP1A2)

AIH-1: Autoimmune hepatitis type 1; AIH-2: Autoimmune hepatitis type 2; APECED: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; ANA: Antinuclear antibodies; SMA: Smooth muscle antibodies; p-ANCA: Perinuclear antineutrophil cytoplasmic antibodies; p-ANNA: Peripheral antineutrophil nuclear antibodies; Anti-ASGP-R: Antibodies against asialoglycoprotein receptor; Anti-SLA/LP: Antibodies against soluble liver antigen/liver pancreas; SEpSEcS: Synthase-converting O-phosphoseryl-tRNA to selenocysteinyl-tRNA; anti-LKM1: Anti-liver kidney microsomal antibodies type 1; CYP2D6: Cytochrome P450 2D6; Anti-LKM3: Anti-liver kidney microsomal antibodies type 3; UGT1: UDP-glucuronosyltransferases; Anti-LC1: Anti-liver cytosol antibodies type 1; FTCD: Formiminotransferase cyclodeaminase; CYP2A6: Cytochrome P450 2A6; CYP1A1: Cytochrome P450 1A1; CYP2B6: Cytochrome P450 2B6; Anti-LM: Antibodies against liver membrane; CYP1A2: Cytochrome P450 1A2.

Citation: Gatselis NK, Zachou K, Koukoulis GK, Dalekos GN. Autoimmune hepatitis, one disease with many faces: Etiopathogenetic, clinico-laboratory and histological characteristics. World J Gastroenterol 2015; 21(1): 60-83
URL: https://www.wjgnet.com/1007-9327/full/v21/i1/60.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i1.60