Human papillomavirus does not have a causal role in colorectal carcinogenesis

Table 2 Human papillomavirus-positive vs human papillomavirus-negative colorectal cancers n (%)

	HPV-positive (11 cancers from 11 patients)	HPV-negative (54 cancers out of 53 patients)	P value
Sex
M	9 (81.8)	34 (64.1)	0.431
F	2 (18.2)	19 (35.9)
M/F	4.5	1.8
Age (yr)
Mean ± SD	68.1 ± 3.1	70.6 ± 10.9
Median	69	72	0.52
Range	38.0-84.0	46.0-92
95%CI	52.9-76.9	67.5-73.6
Localization
Rectum	2 (18.2)	11 (20.4)
Sigmoid	3 (27.3)	18 (33.3)	0.731
Transverse	2 (18.2)	4 (7.4)
Right	4 (36.3)	21 (38.9)
Stage-AJCC 9th
I	3 (27.3)	11 (20.4)
II	4 (36.3)	18 (33.3)	0.481
III	3 (27.3)	24 (44.4)
IV	1 (9.1)	1 (1.9)
T stage
T1	- (-)	6 (11.1)
T2	3 (27.3)	7 (12.9)	0.231
T3	8 (72.7)	33 (61.1)
T4	- (-)	8 (14.9)
N stage
N0	7 (63.6)	29 (53.7)	0.281
N1	1 (9.1)	17 (31.4)
N2	3 (27.)	8 (14.9)
Grading3
G1	- (-)	5 (9.2)
G2	4 (36.36)	16 (29.7)	0.551
G3	6 (63.64)	33 (61.1)
V/L/N4
V/L/N0	2 (33.3)	2 (9.5)	0.311
V/L/N1	4 (66.7)	18 (85.7)
V/L/N2	- (-)	1 (4.8)
Lymph node harvest
Mean ± SD	23.0 ± 11.4	20.6 ± 11.6
Median	20	18	0.532
Range	10-54	6-72
95%CI	15.3-30.6	17.4-23.7
Metastatic nodes
Mean ± SD	3.1 ± 5.7	2.6 ± 6.2	0.822
Median	0	0
Range	0-15	0-30
95%CI	0.7-6.9	0.9-4.3
Lymph node ratio
Mean ± SD	0.15 ± 0.3	0.1 ± 0.2	0.552
Median	0	0
Range	0-0.8	0-0.8
95%CI	0.04-0.3	0.04-0.15

¹χ²;

²t-test;

³G: Data analysis performed on 64 tumors (10 HPV-positive and 54-HPV negative); V/L/N: Perivascular/lymphovascular/perineural invasion;

⁴Data analysis performed on 27 tumors (6 HPV-positive and 21 HPV-negative). Human papillomavirus (HPV) including high risk, probable high risk and low risk HPV.