Clinical outcomes of small cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder

Table 3 Clinicopathologic features of patients with small cell neuroendocrine carcinoma of the gallbladder

Characteristic	Patient 1	Patient 2	Patient 3	Patient 4
Sex	Female	Male	Female	Female
Age, yr	49	66	63	45
Tumor size, cm	1.9	1.5	3	9.5
Operation	RC	RC	C	RC1
Combined adenocarcinoma	-	+	-	+
Gross finding	Polypoid	Fungating	Fungating	Mutilobulated
Lymphovascular invasion	+	-	-	+
Perineural invasion	+	+	+	-
Tumor stage	T2	T2	T2	T3
Lymph node metastasis	0/15	1/2	0/0	1/39
Mitosis (/10 HPF)	2	8	20	22
Synaptophysin	+	+	-	-
Chromogranin A	+	+	-	-
CD56	+	+	+	+
P53	+	+	NA	NA
Ki-67	30%	25%	40%	50%

¹This patient underwent hepatopancreaticoduodenectomy and right hemicolectomy. C: Cholecystectomy; HPF: High-power fields; NA: Not available; RC: Radical cholecystectomy.