FoxM1 overexpression promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma

Table 3 Univariate and multivariate analyses of factors associated with survival of hepatocellular carcinoma patients

Variable	P-value
	Univariate analysis		Multivariate analysis
	RFS P-value	OS	RFS P-value	OS P-value
Gender (male vs female)	0.152	0.331	-	-
Age ( ≤ 50 yr vs > 50 yr)	0.478	0.663	-	-
Underlying disease (HBV vs others)	0.461	0.859	-	-
Liver function (A/B vs C)	0.764	0.493	-	-
Preoperative AFP level ( ≤ 200 ng/mL vs > 200 ng/mL)	0.179	0.228	-	-
Tumor size ( ≤ 8 cm vs > 8 cm)	< 0.002a	0.012a	0.174	0.391
Tumor number ( ≤ 3 vs > 3)	0.002a	0.015a	0.228	0.348
Cirrhotic background (no vs yes)	0.172	0.373	-	-
Macrovascular invasion (no vs yes)	< 0.001a	< 0.001a	< 0.001a	0.003a
Tumor differentiation (G1/G2 vs G3)	0.131	0.179	-	-
TNM stage (I/II vs III)	< 0.001a	0.006a	0.013a	0.011a
FOXM1 expression (low vs high)	0.004a	0.007a	0.012a	0.008a

^aP < 0.05. HBV: Hepatitis B virus; AFP: α-fetoprotein; TNM: Tumor-nodes-metastasis; FoxM1: Forkhead box protein M1; OS: Overall survival; RFS: Relapse-free survival.