Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestine

Table 3 Effect of dietary fat treatment on the histological score induced by indomethacin¹

Lipid	Diet
	R	BT	FO	SO
Without IND (grade)	0.20 ± 0.08	0.30 ± 0.11	0.20 ± 0.07	0.20 ± 0.08
With IND (grade)	3.24 ± 0.31	3.71 ± 0.42ab	3.65 ± 0.31ab	2.64 ± 0.51

¹Values are represented as mean ± SEM, n = 8-12;

^aP < 0.05 vs IND,

^bP < 0.05 vs IND + SO. Grade 0, normal villi structure; grade 1, development of a small subepithelial space at the villous apex; grade 2, enlarged subepithelial space, but no change in villous length and width; grade 3, few shortened villi and presence of cells in the lumen; grade 4, most villi are shortened and widened with crypt hyperplasia and cells in the lumen; and grade 5, blunting of all villi with elongated crypts and a high number of cells in the lumen. IND: Indomethacin; R: Reference diet (CE-2); BT: Beef tallow; FO: Fish oil; SO: Safflower oil.