Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestine

Table 2 Approximate fatty acid profile (percent of total fat)

	Beef tallow	Fish oil	Safflower oil
Myristic (14:0)	3
Palmitic acid (16:0)	26	25.1	7.1
Stearic acid (18:0)	14	4.4	2.5
Oleic acid (18:1)	47	12.9	13.3
Palmitoleic acid (16:1)	3	14.9
Linoleic acid (18:2)	3	2.4	76.0
Linolenic acid (18:3)	1	1.2	0.3
Eicosapentaenoic acid (20:5)		15.6
Docosahexaenoic acid (22:6)		8.8
Others	3	1.5	0.8
Omega-3/omega-6 ratio	1:3	10.6:1	1:255

Dietary fat administration was commenced 1 wk prior to IND administration. Each fat-containing diet consisted of a fat-free AIN76 (Clea Japan, Tokyo) diet and 3 different types of 8% w/w fatty acids. Fatty acid profiles in the fat rich diet were Beef tallow, Fish oil and Safflower oil. CE-2 was given as a reference diet (R).