Establishment and characterization of cell lines from chromosomal instable colorectal cancer

Table 5 IC₅₀ values of antitumor drugs evaluated for colorectal carcinoma cell lines

Cell line	IC50
	5-FU(μg/mL)	Cisplatin(μg/mL)	Irinotecan(μmol/L)	Gemcitabine(μmol/L)	Paclitaxel1	Trastuzumab2	Erlotinib(μmol/L)	Nilotinib(μmol/L)	Rapamycin(μmol/L)
HROC18	0.48 ± 0.28	1.58 ± 0.29	7.88 ± 2.26	3.35 ± 1.18	Resistant	Resistant	12.21 ± 5.4	7.55 ± 1.77	0.08 ± 0.04
HROC32P	0.15 ± 0.07	0.65 ± 0.40	0.15 ± 0.07	3.90 ± 2.16	Resistant	Resistant	1.40 ± 1.01	5.47 ± 3.13	0.14 ± 0.14
HROC32X	1.97 ± 1.95	1.30 ± 0.46	3.83 ± 1.40	5.90 ± 1.06	Resistant	Resistant	0.87 ± 0.15	5.5 ± 3.1	0.13 ± 0.06

¹Range 0.9 nmol/L: 60 mmol/L;

²Range: 310 ng/mL: 20 μg/mL. Values are given as mean, resulting from at least three independent experiments each performed in triplicates. 5-FU: 5-Fluorouracil.